About: Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity

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About: Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity
Creator	Lim, Annick Zhang, Xiaoming Zhivaki, Dania Bastien Lemoine, Sé Correspondence, Man Lo, Richard Tissiè, Pierre
source	Elsevier; Medline; PMC
abstract	Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections in infants and is characterized by pulmonary infiltration of B cells in fatal cases. We analyzed the B cell compartment in human newborns and identified a population of neonatal regulatory B lymphocytes (nBreg cells) that produced interleukin 10 (IL-10) in response to RSV infection. The polyreactive B cell receptor of nBreg cells interacted with RSV protein F and induced upregulation of chemokine receptor CX3CR1. CX3CR1 interacted with RSV glycoprotein G, leading to nBreg cell infection and IL-10 production that dampened T helper 1 (Th1) cytokine production. In the respiratory tract of neonates with severe RSV-induced acute bronchiolitis, RSV-infected nBreg cell frequencies correlated with increased viral load and decreased blood memory Th1 cell frequencies. Thus, the frequency of nBreg cells is predictive of the severity of acute bronchiolitis disease and nBreg cell activity may constitute an early-life host response that favors microbial pathogenesis.
has issue date	2017-02-21(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2017.01.010
bibo:pmid	28228284
has license	no-cc
sha1sum (hex)	b21f6a299e3b5b40ecf2e7ed99e941b3af72b763
schema:url	https://doi.org/10.1016/j.immuni.2017.01.010
resource representing a document's title	Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity
has PubMed Central identifier	PMC7128247
has PubMed identifier	28228284
schema:publication	Immunity
resource representing a document's body	covid:b21f6a299e3b5b40ecf2e7ed99e941b3af72b763#body_text
is schema:about of	named entity 'cells' named entity 'anti-inflammatory' named entity 'Receptor' named entity 'NEONATES' named entity 'OF LUNG DISEASE' named entity 'BIOMARKER' named entity 'INFECTED' named entity 'BLOOD' named entity 'REGULATORY' named entity 'CHEMOKINE RECEPTOR CX3CR1' named entity 'PATIENTS' named entity 'BCR' named entity 'IL-10' named entity 'RSV' named entity 'ABSTRACT' named entity 'SPECIFIC' named entity 'REGULATORY B CELLS' named entity 'ANTI-INFLAMMATORY' named entity 'PRODUCE' named entity 'CX3CR1' named entity 'HUMAN' named entity 'LUNG DISEASE' named entity 'INFECTS' named entity 'DISEASE SEVERITY' named entity 'CELLS' named entity 'TH1 CELL' named entity 'NEONATAL' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'RESPONSES' named entity 'SUBSET' named entity 'DISEASE SEVERITY' named entity 'IDENTIFIED' named entity 'Abstract' named entity 'Neonatal' named entity 'CX3CR1' named entity 'IL-10' named entity '0.01' named entity 'HRSV' named entity 'pDCs' named entity 'CX3CL1' named entity 'biomarker' named entity 'DNA chip' named entity 'virus' named entity 'mCherry' named entity 'CD5' named entity 'CD5' named entity 'RSV' named entity 'Bar chart' named entity 'CD5' named entity 'RSV' named entity 'dendritic cells' named entity 'TLR' named entity 'IAV' named entity 'IL-10' named entity 'infection' named entity 'RSV infection' named entity 'gold standard' named entity 'memory B cells' named entity 'memory cells' named entity 'Data analysis' named entity 'Fluidigm' named entity 'RSV infection' named entity 'RIG-I' named entity 'IL-10' named entity 'cytokine secretion assay' named entity 'RSV' named entity 'IgG' named entity 'RSV' named entity 'RSV' named entity 'CD5' named entity 'IL-13' named entity 'IFN-g' named entity 'BCR' named entity 'CD5' named entity 'mCherry'

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