About: Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening

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About: Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening
Creator	Alves-Rodrigues, Isabel Meyerhans, Andreas Diez, Juana Heinzle, Elmar Schneider, Konstantin Wittmann, Christoph Krömer, Jens
Source	Medline; PMC
abstract	BACKGROUND: The cellular proteins Pat1p, Lsm1p, and Dhh1p are required for the replication of some positive-strand viruses and therefore are potential targets for new antiviral drugs. To prioritize host targets for antiviral drug screening a comparative metabolome analysis in Saccharomyces cerevisiae reference strain BY4742 Matα his3Δ1 leu2Δ0 lys2Δ0 ura3Δ0 and deletion strains pat1Δ, lsm1Δ and dhh1Δ was performed. RESULTS: GC/MS analysis permitted the quantification of 47 polar metabolites and the identification of 41 of them. Metabolites with significant variation between the strains were identified using partial least squares to latent structures discriminate analysis (PLS-DA). The analysis revealed least differences of pat1Δ to the reference strain as characterized by Euclidian distance of normalized peak areas. The growth rate and specific production rates of ethanol and glycerol were also most similar with this strain. CONCLUSION: From these results we hypothesize that the human analog of yeast Pat1p is most likely the best drug target candidate.
has issue date	2009-01-30(xsd:dateTime)
bibo:doi	10.1186/1475-2859-8-12
bibo:pmid	19183481
has license	cc-by
sha1sum (hex)	b23a403b1daf18cd8a06665ad3111e92453bd61b
schema:url	https://doi.org/10.1186/1475-2859-8-12
resource representing a document's title	Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening
has PubMed Central identifier	PMC2658664
has PubMed identifier	19183481
schema:publication	Microb Cell Fact
resource representing a document's body	covid:b23a403b1daf18cd8a06665ad3111e92453bd61b#body_text
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