About: Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
Creator	Gern, James Lynch, Susan Demuri, Gregory Faruqi, Ali Santee, Clark Wald, Ellen Nagalingam, Nabeetha
Source	Medline; PMC
abstract	BACKGROUND: Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI. RESULTS: Healthy children (n = 47) aged 49–84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health outcomes. The composition of the NP bacterial community of children was significantly related prior to the history of acute sinusitis (R(2) = 0.070, P < 0.009). History of acute sinusitis was associated with significant depletion in relative abundance of taxa including Faecalibacterium prausnitzii and Akkermansia spp. and enrichment of Moraxella nonliquefaciens. Enrichment of M. nonliquefaciens was also a characteristic of baseline NP samples of children who subsequently developed acute sinusitis over the 1-year study period. Time to develop URI was significantly positively correlated with NP diversity, and children who experienced more frequent URIs exhibited significantly diminished NP microbiota diversity (P ≤ 0.05). CONCLUSIONS: These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40168-016-0179-9) contains supplementary material, which is available to authorized users.
has issue date	2016-07-01(xsd:dateTime)
bibo:doi	10.1186/s40168-016-0179-9
bibo:pmid	27364497
has license	cc-by
sha1sum (hex)	b293192e82a70515cb199bca870a9fe2ca9b081d
schema:url	https://doi.org/10.1186/s40168-016-0179-9
resource representing a document's title	Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
has PubMed Central identifier	PMC4929776
has PubMed identifier	27364497
schema:publication	Microbiome
resource representing a document's body	covid:b293192e82a70515cb199bca870a9fe2ca9b081d#body_text
is schema:about of	named entity 'IMPORTANT' named entity 'RELATED' named entity 'AFFECT' named entity 'EXAMINED' named entity 'THEIR' named entity 'CHARACTERISTIC' named entity 'FAECALIBACTERIUM PRAUSNITZII' named entity 'COMPLICATIONS' named entity '28P' named entity 'SIGNIFICANT' named entity '070' named entity 'MORAXELLA NONLIQUEFACIENS' named entity 'BACTERIAL' named entity 'USA' named entity 'RESULTS' named entity 'SAMPLES' named entity 'ITS' named entity 'DEMOGRAPHIC CHARACTERISTICS' named entity 'POPULATIONS' named entity 'PERIOD' named entity 'YEAR' named entity 'ACUTE SINUSITIS' named entity 'STUDY' named entity 'UPPER RESPIRATORY INFECTIONS' named entity 'INCLUDING' named entity 'URIS' named entity 'CLINICAL DATA' named entity 'A MAJOR' named entity 'POSITIVELY CORRELATED' named entity 'DIVERSITY' named entity 'BASED' named entity 'DEPLETION' named entity 'MICROBIOLOGY' named entity '0.05' named entity 'ASSOCIATED WITH' named entity 'RELATIVE ABUNDANCE' named entity 'DIMINISHED' named entity 'THESE' named entity 'HEALTHY' named entity 'AKKERMANSIA' named entity 'PRIOR TO' named entity 'SWAB' named entity 'CHILDREN' named entity 'PEDIATRIC' named entity 'RESPIRATORY' named entity 'OBTAINED' named entity 'TAXA' named entity 'EXPERIENCED' named entity 'LITTLE' named entity 'DEMOGRAPHIC' named entity 'URI' named entity 'ENRICHMENT' named entity 'UPPER' named entity 'TIME' named entity 'SPP' named entity 'BASELINE' named entity 'DATA' named entity 'AGED' named entity 'BACKGROUND' named entity 'NASOPHARYNX' named entity 'KNOWN' named entity 'BACTERIAL COMMUNITY' named entity 'FREQUENT' named entity 'USING' named entity 'HEALTHCARE' named entity 'DETERMINANT' named entity 'WISCONSIN' named entity 'COMPOSITION' named entity 'RELATIONSHIP' named entity 'NASOPHARYNGEAL' named entity 'PRECISE' named entity 'PARTICIPANTS' named entity 'PROSPECTIVE COHORT STUDY' named entity 'MICROBIOTA' named entity 'MICROARRAY'

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