About: Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats

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About: Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats
Creator	Holmdahl, Rikard Olofsson, Peter Pettersson, Ulf Nordquist, Niklas Saxne, Tore Vingsbo-Lundberg, Carina
source	Medline; PMC
abstract	Rheumatoid arthritis (RA) is a chronic and genetically complex inflammatory disorder that leads to erosive destruction of peripheral joints(1,2,3,4,5). The use of animal models mimicking RA, such as pristane-induced arthritis (PIA) in rats, should facilitate its genetic analysis. Pristane is a non-immunogenic synthetic oil that, after a single subcutaneous injection into DA rats, induces arthritis restricted to peripheral joints with a chronic relapsing disease course(6). To identify genes involved in the control of chronic arthritis, we made crosses between susceptible DA rats and resistant E3 rats and analysed the progeny with microsatellite markers covering the entire rat genome. Our results show that different arthritis phenotypes are associated with different chromosomal loci. Loci on chromosomes 4 and 6 ( Pia2 and Pia3 ) influence arthritis onset, whereas a locus on chromosome 12 ( Pia4 ) is associated with severity and joint erosion. We found that chronicity is associated with a different set of loci, one on chromosome 4 and the other on chromosome 14 ( Pia5, Pia6 ). These findings demonstrate for the first time that different phases of a chronic self-perpetuative disease which mimics RA are associated with distinct sets of genes.
has issue date	1998-01-01(xsd:dateTime)
bibo:doi	10.1038/3887
bibo:pmid	9843218
has license	no-cc
sha1sum (hex)	b2c5b9e25628586800b84f9529d6f5bf0cef1f75
schema:url	https://doi.org/10.1038/3887
resource representing a document's title	Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats
has PubMed Central identifier	PMC7097458
has PubMed identifier	9843218
schema:publication	Nat Genet
resource representing a document's body	covid:b2c5b9e25628586800b84f9529d6f5bf0cef1f75#body_text
is schema:about of	named entity 'GENETIC CONTROL' named entity 'phases' named entity 'rats' named entity 'erosive' named entity 'restricted' named entity 'CHRONICITY' named entity 'GENETIC ANALYSIS' named entity 'INDUCED' named entity 'PROGENY' named entity 'PHENOTYPES' named entity 'PRISTANE' named entity 'DISEASE COURSE' named entity 'RATS' named entity 'CHROMOSOME 12' named entity 'JOINT' named entity 'LOCUS' named entity 'INFLUENCE' named entity 'IMMUNOGENIC' named entity 'RHEUMATOID ARTHRITIS' named entity 'USE OF' named entity 'CHROMOSOME 14' named entity 'SELF' named entity 'ARTHRITIS' named entity 'SINGLE' named entity 'ASSOCIATED WITH' named entity 'CHROMOSOMES' named entity 'CHRONIC' named entity 'COMPLEX' named entity 'ANIMAL MODELS ' named entity 'EROSION' named entity 'MIMICS' named entity 'DIFFERENT' named entity 'DISTINCT' named entity 'CONTROL' named entity 'LOCI' named entity 'SYNTHETIC' named entity 'SUSCEPTIBLE' named entity 'CROSSES' named entity 'RHEUMATOID ARTHRITIS' named entity 'ARTHRITIS' named entity 'FINDINGS' named entity 'MICROSATELLITE MARKERS' named entity 'THESE' named entity 'JOINTS' named entity 'SUBCUTANEOUS INJECTION' named entity 'PERIPHERAL' named entity 'ENTIRE' named entity 'TIME' named entity 'COVERING' named entity 'ITS' named entity 'CHRONIC ARTHRITIS' named entity 'IS A' named entity 'SEVERITY' named entity 'GENES' named entity 'RESTRICTED' named entity 'ONSET' named entity 'INFLAMMATORY DISORDER' named entity 'CHROMOSOME 4' named entity 'RATS' named entity 'ONSET' named entity 'DISEASE' named entity 'OIL' named entity 'CHROMOSOMAL' named entity 'DESTRUCTION' named entity 'INVOLVED' named entity 'RELAPSING' named entity 'RESULTS' named entity 'LEADS' named entity 'EROSIVE' named entity 'WITH SEVERITY' named entity 'RAT GENOME' named entity 'RESISTANT' named entity 'OUR' named entity 'SET' named entity 'PHASES' named entity 'TO IDENTIFY'

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