About: Effectiveness of Convalescent Plasma for Treatment of COVID-19 Patients

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effectiveness of Convalescent Plasma for Treatment of COVID-19 Patients
Creator	Zhang, Yi Li, Jing Li, Ping Li, Fangfang Ma, Hongwei Wang, ; Chen, ; Chen, Shanshan Kang, Yi Zhang, Guojun Xing, Lihua Chunya, ; Li, Jianbin Sang, Qian Song, Xiangjin Xu, Luyang Yang, Qiankun
source	MedRxiv
abstract	Background and objective: The outbreak of COVID-19 has become a global health concern. In this study, we evaluate the effectiveness and safety of convalescent plasma therapy in patients with severe and critically ill COVID-19. Methods: Sixteen COVID-19 patients received transfusion of anti-COVID-19 antibody-positive convalescent plasma. The main outcome was time for viral nucleic acid amplification (NAA) test turning negative. Clinical laboratory parameters were measured at the baseline (d0) before plasma transfusion, and day 1 (d1), day 3 (d3) after transfusion as well. Results: Among the 16 patients, 10 of them had a consistently positive result of viral NAA test before convalescent plasma transfusion. Eight patients (8/10) became negative from day 2 to day 8 after transfusion. Severe patients showed a shorter time for NAA test turning negative after transfusion (mean rank 2.17 vs 5.90, P = 0.036). Two critically ill patients transfused plasma with lower antibody level remained a positive result of NAA test. CRP level demonstrated a decline 1 day after convalescent plasma treatment, compared with the baseline (P = 0.017). No adverse events were observed during convalescent plasma transfusion. Conclusions: Viral NAA test of most patients with COVID-19 who received convalescent plasma transfusion turned negative on the 2nd to 8th days after transfusion, and the negative time of severe patients was shorter than that of critically ill patients.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1101/2020.08.02.20166710
has license	medrxiv
sha1sum (hex)	b2ed2ea45bc12733d8087b6ebba001093cbfac05
schema:url	https://doi.org/10.1101/2020.08.02.20166710
resource representing a document's title	Effectiveness of Convalescent Plasma for Treatment of COVID-19 Patients
resource representing a document's body	covid:b2ed2ea45bc12733d8087b6ebba001093cbfac05#body_text
is schema:about of	named entity 'convalescent' named entity 'patients' named entity 'COVID-19' named entity 'Treatment' named entity 'EFFECTIVENESS' named entity 'severe' named entity 'evaluate' named entity 'ECMO' named entity 'convalescent plasma' named entity 'convalescent plasma' named entity 'convalescent plasma' named entity 'Henan' named entity 'plasma' named entity 'COVID' named entity 'statistically significant' named entity 'plasma' named entity 'Affiliated Hospital' named entity 'medRxiv' named entity 'medRxiv' named entity 'COVID-19' named entity 'plasma' named entity 'plasma' named entity 'influenza' named entity 'lactic acid' named entity 'NAA' named entity 'medical institution' named entity 'critically ill' named entity 'medRxiv' named entity 'correlation' named entity 'plasma' named entity 'convalescent plasma transfusion' named entity 'normal distribution' named entity 'medRxiv' named entity 'mortality rate' named entity 'preprint' named entity 'extracorporeal membrane oxygenation' named entity 'National Health Commission' named entity 'preprint' named entity 'preprint' named entity 'pathogens' named entity 'medRxiv' named entity 'plasma' named entity 'COVID' named entity 'preprint' named entity 'traditional Chinese medicine' named entity 'convalescent plasma' named entity 'antibody' named entity 'preprint' named entity 'epidemic' named entity 'COVID' named entity 'plasma' named entity 'plasma' named entity 'Wuhan' named entity 'preprint' named entity 'antibody' named entity 'Red Cross' named entity 'preprint' named entity 'medRxiv' named entity 'invasive ventilation' named entity 'antibody' named entity 'Spanish influenza' named entity 'significant difference' named entity 'meta-analysis' named entity 'coronavirus infection' named entity 'invasive ventilation' named entity 'preprint' named entity 'WBC' named entity 'NAA' named entity 'creatine kinase'

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