About: Dilated Cardiomyopathy in Juvenile Portuguese Water Dogs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dilated Cardiomyopathy in Juvenile Portuguese Water Dogs
Creator	Dambach, Donna Armstrong, Clara Bowers, Tim Henthorn, Paula Lankford, Edward Sleeper, Margaret Tijskens, Pierre Vijayasarathy, C
Source	Medline; PMC
abstract	Dilated cardiomyopathy recently has been recognized in juvenile Portuguese Water Dogs. The purpose of this study was to evaluate unaffected and affected puppies by physical examination, electrocardiogram (ECG), echocardiogram, specific biochemical assays, and ultrastructure to document disease progression and to develop a method of early detection. Results of segregation analysis were consistent with autosomal recessive inheritance. Of 124 puppies evaluated clinically and echocardiographically, 10 were affected. No significant differences were found between unaffected and affected puppies for blood and myocardial carnitine or taurine concentrations, serum chemical variables, results of ophthalmological examinations, ECGs, or measurement of urine metabolites. Ultrastructural examination of myocardium from affected dogs revealed myofibrillar atrophy and small regions of myo‐fibrillar degeneration, most prominently at the region of the intercalated discs. Only echocardiography allowed detection of affected puppies before clinical signs became evident. Echocardiography revealed a significant difference in the shortening fraction, E point to septal separation, and the end systolic and diastolic left ventricular internal diameters. Affected puppies were detected 1–4 weeks before the development of acute congestive heart failure.
has issue date	2008-06-28(xsd:dateTime)
bibo:doi	10.1111/j.1939-1676.2002.tb01606.x
bibo:pmid	11822805
has license	no-cc
sha1sum (hex)	b31057b9ef275ab96885f9cfa1b4acae528fb7fa
schema:url	https://doi.org/10.1111/j.1939-1676.2002.tb01606.x
resource representing a document's title	Dilated Cardiomyopathy in Juvenile Portuguese Water Dogs
has PubMed Central identifier	PMC7197504
has PubMed identifier	11822805
schema:publication	J Vet Intern Med
resource representing a document's body	covid:b31057b9ef275ab96885f9cfa1b4acae528fb7fa#body_text
is schema:about of	named entity 'evident' named entity 'myocardium' named entity 'specific' named entity 'puppies' named entity 'shortening' named entity 'Results' named entity 'Water' named entity 'STUDY' named entity 'INTERCALATED' named entity 'PHYSICAL EXAMINATION' named entity 'evaluate' named entity 'clinical signs' named entity 'systolic' named entity 'evaluated' named entity 'inheritance' named entity 'puppies' named entity 'diameters' named entity 'ECG' named entity 'biochemical assays' named entity 'taurine' named entity 'left ventricular' named entity 'urine' named entity 'diastolic' named entity 'titin' named entity 'fatty acids' named entity 'myofibrils' named entity 'DCM' named entity 'clinical signs' named entity 'sarcoglycan' named entity 'DCM' named entity 'carnitine' named entity 'postmortem' named entity 'mitochondrial gene' named entity 'contractile function' named entity 'Klenow' named entity 'serum' named entity 'Histopathology' named entity 'reduced nicotinamide adenine dinucleotide' named entity 'prognosis' named entity 'afterload' named entity 'hematoxylin and eosin' named entity 'DCM' named entity 'dCTP' named entity 'Echocardiographic' named entity 'mitochondrial enzyme' named entity 'echocardiographic' named entity 'messenger RNA' named entity 'echocardiographic' named entity 'sarcoplasmic reticulum' named entity 'echocardiographic' named entity 'myofibril' named entity 'electrocardiography' named entity '1.6' named entity 'dystrophin' named entity 'plasma' named entity 'organic acids' named entity 'L-carnitine' named entity 'Immunohistochemistry' named entity 'taurine' named entity 'congestive heart failure' named entity 'Basset Hounds' named entity 'sarcomere' named entity 'intercalated discs' named entity 'troponin' named entity 'mitochondrial inheritance' named entity 'protein' named entity 'anecdotal reports' named entity 'congestive heart failure' named entity 'mitochondrial' named entity 'sinus tachycardia' named entity '3.5' named entity 'drug-induced' named entity 'recessive' named entity 'enlarged heart'

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