About: Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide()

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide()
Creator	Chen, Yu-Dong Dong, Cai-Wen Gui, Jian-Fang Li, Yang-Yang Zhang, Fu-Tie Zhang, Qi-Ya Zhang, Yi-Bing Zhu, Rong
source	Elsevier; Medline; PMC
abstract	Cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions. In this study, Paralichthys olivaceus cathepsin B (PoCatB) cDNA was isolated from flounder embryonic cells (FEC) treated with UV-inactivated grass carp hemorrhage virus (GCHV) and subsequently identified as a virally induced gene. The full length cDNA of PoCatB is 1801 bp encoding 330-amino acids. The deduced protein has high homology to all known cathepsin B proteins, containing an N-terminal signal peptide, cysteine protease active sites, the occluding loop segment and a glycosylation site, all of which are conserved in the cathepsin B family. PoCatB transcription of FEC cells could be induced by turbot (Scophthalmus maximus) rhabdovirus (SMRV), UV-inactivated SMRV, UV-inactivated GCHV, poly I:C or lipopolysaccharide (LPS), and SMRV or poly I:C was revealed to be most effective among the five inducers. In normal flounder, PoCatB mRNA was detectable in all examined tissues. Moreover, SMRV infection could result in significant upregulation of PoCatB mRNA, predominantly in spleen, head kidney, posterior kidney, intestine, gill and muscle with 18.2, 10.9, 24.7, 12, 31.5 and 18 fold increases at 72 h post-infection respectively. These results provided the first evidence for the transcriptional induction of cathepsin B in fish by virus and LPS, indicating existence of a novel function in viral defense.
has issue date	2008-08-07(xsd:dateTime)
bibo:doi	10.1016/j.fsi.2008.07.018
bibo:pmid	18755278
has license	no-cc
sha1sum (hex)	b32e3e2b7c3598deea425036dc4d39bc5910e799
schema:url	https://doi.org/10.1016/j.fsi.2008.07.018
resource representing a document's title	Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide()
has PubMed Central identifier	PMC7111675
has PubMed identifier	18755278
schema:publication	Fish Shellfish Immunol
resource representing a document's body	covid:b32e3e2b7c3598deea425036dc4d39bc5910e799#body_text
is schema:about of	named entity 'PARALICHTHYS OLIVACEUS' named entity 'function' named entity 'encoding' named entity 'viral' named entity 'virus' named entity 'cathepsin B' named entity 'N-terminal' named entity 'induction' named entity 'cysteine protease' named entity 'FEC' named entity 'detectable' named entity 'virus' named entity 'Paralichthys olivaceus' named entity 'POLY I' named entity 'SPLEEN' named entity 'SIGNIFICANT' named entity 'THESE' named entity 'EFFECTIVE' named entity 'PARALICHTHYS OLIVACEUS' named entity 'RESULTS' named entity 'CDNA' named entity 'NORMAL' named entity 'RHABDOVIRUS' named entity 'TURBOT' named entity 'N-TERMINAL ' named entity 'REVEALED' named entity 'UPREGULATION' named entity 'ENCODING' named entity 'AMINO ACIDS' named entity 'PROVIDED' named entity 'HIGH' named entity 'FEC' named entity 'LOOP' named entity 'BIOLOGICAL FUNCTIONS' named entity 'MRNA' named entity 'FOLD' named entity 'IS A' named entity 'POSTERIOR KIDNEY' named entity 'OCCLUDING' named entity 'PROTEIN ' named entity 'SMRV' named entity 'INFECTION' named entity 'EXAMINED' named entity 'LIPOPOLYSACCHARIDE' named entity '330' named entity 'ENZYME' named entity 'POLY I' named entity 'FAMILY' named entity 'DETECTABLE' named entity 'FUNCTION' named entity 'INDICATING' named entity 'INCREASES' named entity 'PAPAIN' named entity 'MUSCLE' named entity 'GILL' named entity 'GLYCOSYLATION SITE' named entity 'VIRUS' named entity 'CYSTEINE PROTEASE' named entity 'FISH' named entity 'ISOLATED' named entity 'CONTAINING' named entity 'RESPONSE TO VIRUS' named entity 'INTESTINE' named entity 'VIRAL' named entity 'EVIDENCE FOR' named entity 'IDENTIFIED' named entity 'STUDY' named entity 'TRANSCRIPTIONAL INDUCTION' named entity 'LPS' named entity 'CATHEPSIN B GENE' named entity 'TRANSCRIPTION' named entity 'CELLS' named entity 'GENE' named entity 'SEGMENT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software