About: Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough

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About: Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough
Creator	Zhou, Min Franco, Luis Khan, Haaris Ruhl, Cody Shiloh, Michael Burton, Michael Correspondence, Michael Davis, Colton Dussor, Gregory Gautron, Laurent Hsia, Connie Kindt, Lexy Mejia, Galo Naik, Dhananjay Pasko, Breanna Price, Theodore Qin, Tian Stamm, Chelsea
Source	Elsevier; Medline; PMC
abstract	Summary Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests with a persistent cough as both a primary symptom and mechanism of transmission. The cough reflex can be triggered by nociceptive neurons innervating the lungs, and some bacteria produce neuron-targeting molecules. However, how pulmonary Mtb infection causes cough remains undefined, and whether Mtb produces a neuron-activating, cough-inducing molecule is unknown. Here, we show that an Mtb organic extract activates nociceptive neurons in vitro and identify the Mtb glycolipid sulfolipid-1 (SL-1) as the nociceptive molecule. Mtb organic extracts from mutants lacking SL-1 synthesis cannot activate neurons in vitro or induce cough in a guinea pig model. Finally, Mtb-infected guinea pigs cough in a manner dependent on SL-1 synthesis. Thus, we demonstrate a heretofore unknown molecular mechanism for cough induction by a virulent human pathogen via its production of a complex lipid.
has issue date	2020-03-05(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.02.026
bibo:pmid	32142653
has license	els-covid
sha1sum (hex)	b3528add37d78281040babe78cffa1b58a9c5b62
schema:url	https://doi.org/10.1016/j.cell.2020.02.026
resource representing a document's title	Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough
has PubMed Central identifier	PMC7102531
has PubMed identifier	32142653
schema:publication	Cell
resource representing a document's body	covid:b3528add37d78281040babe78cffa1b58a9c5b62#body_text
is schema:about of	named entity 'original' named entity 'database' named entity 'extract' named entity 'NTM' named entity 'epidemiologic data' named entity 'sulfated' named entity 'lipids' named entity 'leukotriene' named entity 'cough' named entity 'cell wall' named entity 'TRPV1' named entity 'lipid' named entity 'centrifuged' named entity 'Chemosensory' named entity 'glucose' named entity 'cell wall' named entity 'M. avium' named entity 'neuronal activation' named entity 'capsaicin' named entity 'pathology' named entity 'cough' named entity 'dairy products' named entity 'sensory nerves' named entity 'mycolactone' named entity 'nebulizing' named entity 'inhalation' named entity 'DMSO' named entity 'guinea pigs' named entity 'cough' named entity 'molecule' named entity 'agonist' named entity 'infection' named entity 'D-lysine' named entity 'guinea pigs' named entity 'cell wall' named entity 'guinea pigs' named entity 'sulfated' named entity 'damage-associated molecular pattern' named entity 'pulmonary tuberculosis' named entity 'MED17' named entity 'COVID' named entity 'nociceptive' named entity 'glutamine' named entity 'gram-negative' named entity 'DMSO' named entity 'ng/mL' named entity 'cough' named entity 'SL-1' named entity 'sulfated' named entity 'neuronal activation' named entity 'SL-1' named entity 'capsaicin' named entity 'neurons' named entity 'neuronal activation' named entity 'afferent neurons' named entity 'cough' named entity 'neuronal cell' named entity 'cough' named entity 'culture media' named entity 'intracellular' named entity 'nebulization' named entity 'E. coli' named entity 'hypersensitivity' named entity 'Mann-Whitney'

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