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About:
Influence of H7N9 virus infection and associated treatment on human gut microbiota
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Influence of H7N9 virus infection and associated treatment on human gut microbiota
Creator
Zheng, Beiwen
Liu, Lin
Li, Ang
Li, Lanjuan
Liang, Weifeng
Zhu, Yixin
Yao, Jian
Guo, Jing
Zhou, Jiawei
Xiao, Yonghong
Guo, Lihua
Dusko Ehrlich, S
Ni, Shujun
Qin, Nan
Wu, Lingjiao
Zuo, Jian
source
PMC
abstract
Between March and June, 2013, forty H7N9 patients were hospitalized in our hospital. Next-generation sequencing technologies have been used to sequence the fecal DNA samples of the patient, the within sample diversity analysis, enterotyping, functional gene and metagenomic species analysis have been carried on both the patients and healthy controls. The influence of associated treatment in H7N9 infected patients is dramatic and was firstly revealed in species level due to deep sequencing technology. We found that most of the MetaGenomic Species (MGS) enriched in the control samples were Roseburia inulinivorans DSM 16841, butyrate producing bacterium SS3/4 and most of MGS enriched in the H7N9 patients were Clostridium sp. 7 2 43FAA and Enterococcus faecium. It was concluded that H7N9 viral infection and antibiotic administration have a significant effect on the microbiota community with decreased diversity and overgrowth of the bacteria such as Escherichia coli and Enterococcus faecium. Enterotype analysis showed that the communities were unstable. Treatment including antivirals, probiotics and antibiotics helps to improve the microbiota diversity and the abundance of beneficial bacteria in the gut.
has issue date
2015-10-22
(
xsd:dateTime
)
bibo:doi
10.1038/srep14771
bibo:pmid
26490635
has license
cc-by
sha1sum (hex)
b3687e742ed6add38920cfcd8c82bc1642e4928e
schema:url
https://doi.org/10.1038/srep14771
resource representing a document's title
Influence of H7N9 virus infection and associated treatment on human gut microbiota
has PubMed Central identifier
PMC4614822
has PubMed identifier
26490635
schema:publication
Sci Rep
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covid:b3687e742ed6add38920cfcd8c82bc1642e4928e#body_text
is
schema:about
of
named entity 'hospitalized'
named entity 'producing'
named entity 'faecium'
named entity 'MGS'
named entity 'BENEFICIAL'
named entity 'THE GUT'
named entity 'MARCH'
named entity 'CONTROLS'
named entity 'SAMPLE'
named entity 'PATIENTS'
named entity 'USED'
named entity 'COMMUNITY'
named entity 'MICROBIOTA'
named entity 'ROSEBURIA INULINIVORANS'
named entity 'INFECTED'
named entity 'ENTEROCOCCUS FAECIUM'
named entity 'HAVE'
named entity 'SEQUENCE'
named entity 'FIRSTLY'
named entity 'patients'
named entity 'carried'
named entity 'T2D'
named entity 'bacterial translocation'
named entity 'Zhejiang University'
named entity 'gene markers'
named entity 'microbiota'
named entity 'Zhejiang'
named entity 'Klebsiella'
named entity 'sequencing technology'
named entity 'Scientific RepoRts'
named entity 'microbial communities'
named entity 'H7N9'
named entity 'gut microbiota'
named entity 'respiratory tract diseases'
named entity 'Clostridium butyricum'
named entity 'H7N9'
named entity 'data set'
named entity 'butyrate'
named entity 'genus'
named entity 'informed consent'
named entity 'Zhejiang University'
named entity 'gene'
named entity 'sample'
named entity 'Escherichia'
named entity 'Shannon index'
named entity 'B. Subtilis'
named entity 'T2D'
named entity 'microbial communities'
named entity 'infection'
named entity 'Clostridium'
named entity 'Helsinki'
named entity 'infection'
named entity 'MetaGene'
named entity 'genus'
named entity 'NCBI'
named entity 'Bacteroides'
named entity 'type-2 diabetes'
named entity 'H7N9'
named entity 'gut microbiota'
named entity 'probiotic'
named entity 'ORFs'
named entity 'H7N9'
named entity 'Salmonella'
named entity 'piperacillin'
named entity 'urinary tract infections'
named entity 'genomes'
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