About: Viral cysteine proteinases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral cysteine proteinases
Creator	Snijder, Eric Chumakov, ~m Gorbalenya ~', Alexander
Source	PMC
abstract	Dozens of novel cysteine proteinases have been identified in positive single-stranded RNA viruses and, for the first time, in large double-stranded DNA viruses. The majority of these proteins are distantly related to papain or chymotrypsin and may be direct descendants of primordial proteolytic enzymes. Virus genome synthesis and expression, virion formation, virion entry into the host cell, as well as cellular architecture and functioning can be under the control of viral cysteine proteinases during infection. RNA virus proteinases mediate their liberation from giant multidomain precursors in which they tend to occupy conserved positions. These proteinases possess a narrow substrate specificity, can cleave in cis and in trans, and may also have additional, nonproteolytic functions. The mechanisms of catalysis, substrate recognition and RNA binding were highlighted by the recent analysis of the three-dimensional structure of the chymotrypsin-like cysteine proteinases of two RNA viruses.
has issue date	1996-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02174046
bibo:pmid	32288276
has license	no-cc
sha1sum (hex)	b3a8f18bedad0bc7c198dc960c89b362f1b2587a
schema:url	https://doi.org/10.1007/bf02174046
resource representing a document's title	Viral cysteine proteinases
has PubMed Central identifier	PMC7104566
has PubMed identifier	32288276
schema:publication	Perspect Drug Discov Des
resource representing a document's body	covid:b3a8f18bedad0bc7c198dc960c89b362f1b2587a#body_text
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