About: Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis

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About: Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis
Creator	Corrêa-Oliveira, Rodrigo Vitoriano-Souza, Juliana Menezes-Souza, Daniel Aguiar-Soares, Oliveira Das, Nádia Dian, Rodrigo Giunchetti, Rodolfo Mendes Roatt, Bruno Moreira, Dores Reis, Alexandre De Oliveira Cardoso, Mirelle Guerra De Sá, Renata Martins Carneiro, Cláudia Siqueira-Mathias, Fernando
Source	Elsevier; Medline; PMC
abstract	Abstract The complex interplay between cytokines and chemokines regulates innate and adaptive immune responses against pathogens; specifically, cytokine and chemokine expression drives activation of immune effector cells and their recruitment to tissue infection sites. Herein, we inoculated dogs with Leishmania braziliensis antigens plus saponin (the LBSap vaccine), as well as with the vaccine components, and then used real-time PCR to evaluate the kinetics of dermal expression of mRNAs of cytokines (IL-12, IFN-γ, TNF-α, IL-4, IL-13, TGF-β and IL-10) and chemokines (CCL2, CCL4, CCL5, CCL21 and CXCL8) 1, 12, 24 and 48h after inoculation. We also evaluated the correlation between cytokine and chemokine expression and dermal cellularity. The LBSap vaccine induced high levels of IL-12 and IL-10 expression at 12 and 24h, respectively. Furthermore, we observed positive correlations between IL-12 and IL-13 expression, IFN-γ and IL-13 expression, and IL-13 and TGF-β expression, suggesting that a mixed cytokine microenvironment developed after immunization with the vaccine. Inoculation with the saponin adjuvant alone induced a chemokine and cytokine expression profile similar to that observed in the LBSap group. CCL4 and CXCL8 chemokine expression was up regulated by the LBSap vaccine. CCL5 expression was initially highest in the LBSap group, but at 48h, expression was highest in the LB group. Information about the kinetics of the immune response to this vaccine gained using this dog model will help to elucidate the mechanisms of and factors involved in a protective response against Leishmania infection and will aid in establishing rational approaches for the development of vaccines against canine visceral leishmaniasis.
has issue date	2013-12-31(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2013.05.231
bibo:pmid	23911411
has license	els-covid
sha1sum (hex)	b3c2b6ed518ecf24eee08022fadcff0a0738f76e
schema:url	https://doi.org/10.1016/j.molimm.2013.05.231
resource representing a document's title	Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis
has PubMed Central identifier	PMC7112513
has PubMed identifier	23911411
schema:publication	Molecular Immunology
resource representing a document's body	covid:b3c2b6ed518ecf24eee08022fadcff0a0738f76e#body_text
is schema:about of	named entity 'LEVELS' named entity 'CXCL8 CHEMOKINES' named entity 'PATHOGENS' named entity 'COMPLEX' named entity 'INDUCED' named entity 'ADAPTIVE IMMUNE RESPONSES' named entity 'IL-10' named entity 'EXPRESSION' named entity 'CCL4' named entity 'IMMUNE' named entity 'CHEMOKINES' named entity 'LEISHMANIA INFECTION' named entity 'IL-12' named entity 'IMMUNIZATION' named entity 'MIXED' named entity 'ACTIVATION' named entity 'RESPONSE' named entity 'LEISHMANIA BRAZILIENSIS' named entity 'CELLS' named entity 'CXCL8' named entity 'TISSUE' named entity 'REAL-TIME PCR ' named entity 'HIGHEST' named entity 'ABOUT' named entity 'IL-10' named entity 'expression' named entity 'Information' named entity 'complex' named entity 'CCL2' named entity 'cytokine' named entity 'vaccine' named entity 'immunized' named entity 'vaccine' named entity 'CXCL8' named entity 'DERMIS' named entity 'HIGH' covid:arg/b3c2b6ed518ecf24eee08022fadcff0a0738f76e named entity 'CANINE VISCERAL LEISHMANIASIS' named entity 'GROUP' named entity 'LEVELS' named entity 'CHEMOKINE' named entity 'INOCULATION' named entity 'IMMUNE RESPONSE' named entity 'DERMAL' named entity 'IL-10' named entity 'IL-12' named entity 'CCL4' named entity 'CCL5' named entity 'IL-13' named entity 'CYTOKINES' named entity 'EFFECTOR' named entity 'KINETICS' named entity 'CYTOKINE ' named entity 'MICROENVIRONMENT' named entity 'HIGH' named entity 'CCL21' named entity 'MECHANISMS' named entity 'IFN' named entity 'INFECTION SITES' named entity '90%' named entity 'DEVELOPMENT' named entity 'CCL5' named entity 'DOGS' named entity 'DISPLAYED' named entity 'CYTOKINES' named entity 'IMMUNIZED' named entity 'CYTOKINE EXPRESSION PROFILE' named entity 'USED'

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