About: Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017

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About: Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
Creator	Fontanet, Arnaud Assiri, Abdullah Cauchemez, Simon Van Kerkhove, Maria Ki, Moran Nikolay, Birgit Bernard-Stoecklin, Sibylle El Bushra, Hassan Malik, Rahman Aziz Bin Saeed, Abdul Ben Embarek, Karim
Source	Medline; PMC
abstract	Since its emergence in 2012, 2,260 cases and 803 deaths due to Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization. Most cases were due to transmission in healthcare settings, sometimes causing large outbreaks. We analyzed epidemiologic and clinical data of laboratory-confirmed MERS-CoV cases from eleven healthcare-associated outbreaks in the Kingdom of Saudi Arabia and the Republic of Korea between 2015–2017. We quantified key epidemiological differences between outbreaks. Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. In multivariate analyses, age ≥65 (OR 4.8, 95%CI: 2.6–8.7) and the presence of underlying comorbidities (OR: 2.7, 95% CI: 1.3–5.7) were associated with increased mortality whereas working as healthcare personnel was protective (OR 0.07, 95% CI: 0.01–0.34). At the start of these outbreaks, the reproduction number ranged from 1.0 to 5.7; it dropped below 1 within 2 to 6 weeks. This study provides a comprehensive characterization of MERS HCA-outbreaks. Our results highlight heterogeneities in the epidemiological profile of healthcare-associated outbreaks. The limitations of our study stress the urgent need for standardized data collection for high-threat respiratory pathogens, such as MERS-CoV.
has issue date	2019-05-14(xsd:dateTime)
bibo:doi	10.1038/s41598-019-43586-9
bibo:pmid	31089148
has license	cc-by
sha1sum (hex)	b3e5d96ea8379f9890861c6a1c0246f2b93e833a
schema:url	https://doi.org/10.1038/s41598-019-43586-9
resource representing a document's title	Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
has PubMed Central identifier	PMC6517387
has PubMed identifier	31089148
schema:publication	Sci Rep
resource representing a document's body	covid:b3e5d96ea8379f9890861c6a1c0246f2b93e833a#body_text
is schema:about of	named entity 'RIYADH' named entity 'respiratory' named entity 'epidemiologic' named entity 'dropped' named entity 'standardized' named entity 'MERS-CoV' named entity 'healthcare-associated' named entity 'MERS-COV' named entity 'HEALTH' named entity 'PERCENT' named entity 'UNDERLYING' named entity 'STRESS' named entity 'CAUSING' named entity 'PRESENCE OF' named entity 'ASSOCIATED' named entity 'TWENTY-FIVE' covid:arg/b3e5d96ea8379f9890861c6a1c0246f2b93e833a named entity 'ASSOCIATED WITH' named entity 'SETTINGS' named entity 'ITS' named entity 'WORKING' named entity 'PERSONNEL' named entity 'HEALTHCARE' named entity 'SAUDI ARABIA' named entity '4.8' named entity 'TRANSMISSION' named entity 'DUE TO' named entity 'ACQUIRED' named entity 'ANALYZED' named entity '8.7' named entity 'COMORBIDITIES' named entity 'LABORATORY' named entity 'HAVE' named entity 'RESULTS' named entity '0.01' named entity 'AGE' named entity 'THREAT' named entity 'MERS' named entity 'OUTBREAKS' named entity '1.3' named entity 'CONFIRMED' named entity '803' named entity 'INCREASED MORTALITY' named entity 'EMERGENCE' named entity 'THESE' named entity '0.07' named entity 'SETTING' named entity 'DATA COLLECTION' named entity 'WORLD HEALTH ORGANIZATION' named entity 'DEATHS' named entity 'REPORTED' named entity 'NEED FOR' named entity 'URGENT' named entity '5.7' named entity 'HCA' named entity '2.7' named entity '105' named entity 'HIGH' named entity 'STUDY' named entity 'HOSPITAL' named entity 'OUR' named entity 'REPUBLIC OF KOREA' named entity 'CLINICAL DATA' named entity 'PROVIDES' named entity 'INFECTION' named entity 'LIMITATIONS' named entity 'KEY' named entity '2015' named entity 'DROPPED' named entity 'CHARACTERIZATION' named entity '6 WEEKS'

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