About: NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry

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About: NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry
Creator	Wakita, Takaji Li, Wenhui Watashi, Koichi Urban, Stephan
Source	Medline; PMC
abstract	Chronic hepatitis B virus (HBV) infection, affecting approximately 240 million people worldwide, is a major public health problem that elevates the risk of developing liver cirrhosis and hepatocellular carcinoma. Given that current anti-HBV drugs are limited to interferon-based regimens and nucleos(t)ide analogs, the development of new anti-HBV agents is urgently needed. The viral entry process is generally an attractive target implicated in antiviral strategies. Using primary cells from humans and Tupaia belangeri, as well as HepaRG cells, important determinants of viral entry have been achieved. Recently, sodium taurocholate cotransporting polypeptide (NTCP) was identified as an HBV entry receptor and enabled the establishment of a susceptible cell line that can efficiently support HBV infection. This finding will allow a deeper understanding of the requirements for efficient HBV infection, including the elucidation of the molecular entry mechanism. In addition, pharmacological studies suggest that NTCP is able to serve as a therapeutic target. This article summarizes our current knowledge on the mechanisms of HBV entry and the role of NTCP in this process.
has issue date	2014-02-19(xsd:dateTime)
bibo:doi	10.3390/ijms15022892
bibo:pmid	24557582
has license	cc-by
sha1sum (hex)	b3e94bce63878a41d45d22c012a9492d079b3b7f
schema:url	https://doi.org/10.3390/ijms15022892
resource representing a document's title	NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry
has PubMed Central identifier	PMC3958888
has PubMed identifier	24557582
schema:publication	Int J Mol Sci
resource representing a document's body	covid:b3e94bce63878a41d45d22c012a9492d079b3b7f#body_text
is schema:about of	named entity 'FINDING' named entity 'POLYPEPTIDE' named entity 'USING' named entity 'RECEPTOR' named entity 'HEPATITIS B VIRUS' named entity 'IDENTIFIED' named entity 'INTERFERON' named entity 'RISK OF' named entity 'KNOWLEDGE' named entity 'PHARMACOLOGICAL STUDIES' named entity 'ROLE' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'REGIMENS' named entity 'NEEDED' named entity 'ARTICLE' named entity 'REQUIREMENTS' named entity 'APPROXIMATELY' named entity 'LIVER CIRRHOSIS' named entity 'CELL LINE' named entity 'RECENTLY' named entity 'OUR' named entity 'INCLUDING' named entity 'MOLECULAR' named entity 'public health' named entity 'receptor' named entity 'Given' named entity 'cells' named entity 'viral entry' named entity 'UNDERSTANDING' named entity 'NTCP' named entity 'ELEVATES' named entity 'ADDITION' named entity 'ALLOW' named entity 'PRIMARY CELLS' named entity 'SUPPORT' named entity 'LIMITED' named entity 'PROCESS' named entity 'DEVELOPMENT' named entity 'TO SERVE AS' named entity 'CHRONIC HEPATITIS B' named entity 'CELLS' named entity 'EFFICIENT' named entity 'PUBLIC HEALTH' named entity 'NEW' named entity 'TUPAIA BELANGERI' named entity 'ANTIVIRAL' named entity 'BASED' named entity 'IS A' named entity 'ANTI-HBV AGENTS' named entity 'HEPARG' named entity 'ANALOGS' named entity 'HBV INFECTION' named entity 'WORLDWIDE' named entity 'HEPATITIS B VIRUS' named entity 'DOOR' named entity 'NTCP' named entity 'BEYOND' named entity 'DRUGS' named entity 'AFFECTING' named entity 'GENERALLY' named entity 'THERAPEUTIC TARGET' named entity 'VIRAL ENTRY' named entity 'ESTABLISHMENT' named entity 'IMPORTANT' named entity 'DETERMINANTS' named entity 'MECHANISMS' named entity 'HEALTH PROBLEM' named entity 'HAVE' named entity 'INFECTION' named entity 'GIVEN' named entity 'HUMANS' named entity 'VIRUS ENTRY' named entity 'OPENING' named entity 'DEVELOPING' named entity 'STRATEGIES' named entity 'HBV' named entity 'SUSCEPTIBLE' named entity 'PEOPLE'

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