About: Influenza-associated aspergillosis in critically-ill patients

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About: Influenza-associated aspergillosis in critically-ill patients—a retrospective bicentric cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influenza-associated aspergillosis in critically-ill patients—a retrospective bicentric cohort study
Creator	Schrenzel, Jacques Kaiser, Laurent Pugin, Jérôme Iten, Anne Albrich, Werner »more»
source	PMC
abstract	Influenza was recently reported as a risk factor for invasive aspergillosis (IA). We aimed to describe prognostic factors for influenza-associated IA (IAA) and poor outcome and mortality in critically ill patients in Switzerland. All adults with confirmed influenza admitted to the ICU at two Swiss tertiary care centres during the 2017/2018 influenza season were retrospectively evaluated. IAA was defined by clinical, mycological and radiological criteria: a positive galactomannan in bronchoalveolar lavage or histopathological or cultural evidence in respiratory specimens of Aspergillus spp., any radiological infiltrate and a compatible clinical presentation. Poor outcome was defined as a composite of in-hospital mortality, ICU length of stay (LOS), invasive ventilation for > 7 days or extracorporeal membrane oxygenation. Of 81 patients with influenza in the ICU, 9 (11%) were diagnosed with IAA. All patients with IAA had poor outcome compared to 26 (36%) patients without IAA (p < 0.001). Median ICU-LOS and mortality were 17 vs. 3 days (p < 0.01) and 3/9 (33%) vs. 13/72 (18%; p = 0.37) in patients with vs. without IAA, respectively. Patients with IAA had significantly longer durations of antibiotic therapy, vasoactive support and mechanical ventilation. Aspergillus was the most common respiratory co-pathogen (9/40, 22%) followed by classical bacterial co-pathogens. IAA was not associated with classical risk factors. Aspergillus is a common superinfection in critically ill influenza patients associated with poor outcome and longer duration of organ supportive therapies. Given the absence of classical risk factors for aspergillosis, greater awareness is necessary, particularly in those requiring organ supportive therapies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10096-020-03923-7) contains supplementary material, which is available to authorized users.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.1007/s10096-020-03923-7
has license	no-cc
sha1sum (hex)	b42b654037d93035e1f3b0ac33ebea44545be682
schema:url	https://doi.org/10.1007/s10096-020-03923-7
resource representing a document's title	Influenza-associated aspergillosis in critically-ill patients—a retrospective bicentric cohort study
has PubMed Central identifier	PMC7266735
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:b42b654037d93035e1f3b0ac33ebea44545be682#body_text
is schema:about of	named entity 'therapy' named entity 'evaluated' named entity 'IAA' named entity 'defined' named entity 'All' »more»

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