About: Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in Covid-19-naive individuals

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About: Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in Covid-19-naive individuals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in Covid-19-naive individuals
Creator	Lee, So Bizkarguenaga, Maider Bruzzone, Chiara Embade, Nieves Millet, Oscar Abrescia, Nicola Antoñana-Vildosola, Asier Bosch, Alexandre Egia-Mendikute, Leire García Del Río, Ana Jimenez-Lasheras, Borja Mato, Jose Palazon, Asis Prieto-Fernández, Endika
source	MedRxiv
abstract	We have developed a novel multiplexed flow cytometric bead array (C19BA) for the detection of SARS-CoV-2 seroconversion that allows sensitive identification of IgG and IgM antibodies against three immunogenic proteins: the spike receptor-binding domain (RBD), the spike protein subunit 1 (S1) and the nucleoprotein (N) simultaneously. This assay is more sensitive than ELISA, and the combination of three antigens allows for the interrogation of full seroconversion. Importantly, we have detected N-reactive antibodies in COVID-19-negative individuals.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1101/2020.07.28.20162941
has license	medrxiv
sha1sum (hex)	b44df9a826b14808ccaad41068e482fa9c406995
schema:url	https://doi.org/10.1101/2020.07.28.20162941
resource representing a document's title	Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in Covid-19-naive individuals
resource representing a document's body	covid:b44df9a826b14808ccaad41068e482fa9c406995#body_text
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