About: Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination

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About: Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination
Creator	Campbell, M Chege+, G Hart, C Mwenda+, J Snodgrass, D
Source	Elsevier; Medline; PMC
abstract	Abstract A rhesus rotavirus vaccine adjuvanted with ISCOMs was injected intramuscularly to 5 pregnant baboons, with repeated doses 1–2 and 14 weeks after delivery. Maternal blood and milk samples and blood samples from their babies were collected at 2-weekly intervals until 26 weeks after parturition. Samples were assayed for rotavirus antibodies by ELISAs and neutralisation tests. Vaccination produced statistically significant increases in maternal serum IgG and neutralising antibodies, and in milk IgA, IgG, and neutralising antibodies. Control baboon mothers sampled from 12 weeks after delivery had lower serum and milk antibody titres, but responded to vaccination at 16 weeks by producing a similar antibody profile in serum and milk to those previously vaccinated. Because of the endemic nature of human rotaviral infections, similar maternal vaccinations have potential as a means of increasing milk antibodies to a level at which they may be protective to infants.
has issue date	1995-12-31(xsd:dateTime)
bibo:doi	10.1016/0264-410x(95)98265-c
bibo:pmid	7793139
has license	els-covid
sha1sum (hex)	b48c350f6d3b7087b3260e04b26f8db5ca3bc214
schema:url	https://doi.org/10.1016/0264-410x%2895%2998265-c
resource representing a document's title	Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination
has PubMed Central identifier	PMC7130768
has PubMed identifier	7793139
schema:publication	Vaccine
resource representing a document's body	covid:b48c350f6d3b7087b3260e04b26f8db5ca3bc214#body_text
is schema:about of	named entity 'produced' named entity 'weeks' named entity 'nature' named entity 'human' named entity 'parenteral' named entity 'antibodies' named entity 'MATERNAL' named entity 'MEANS' named entity 'PREGNANT' named entity 'MATERNAL BLOOD' named entity 'POTENTIAL' named entity 'THEIR' named entity 'WEEKLY' named entity 'AFTER DELIVERY' named entity 'VACCINATIONS' named entity 'NEUTRALISING ANTIBODIES' named entity 'ISCOMS' named entity 'SIMILAR' named entity 'ANTIBODY TITRES' named entity 'ANTIBODIES' named entity 'NATURE' named entity 'BLOOD SAMPLES' named entity 'DOSES' named entity '12 WEEKS' named entity 'STATISTICALLY SIGNIFICANT' named entity 'COLLECTED' named entity 'BUT' named entity 'PREVIOUSLY' named entity 'ROTAVIRAL INFECTIONS' named entity 'INTERVALS' named entity 'BABOONS' named entity 'ANTIBODY' named entity '26 WEEKS' named entity 'LOWER' named entity 'PARENTERAL' named entity '16 WEEKS' named entity 'BABIES' named entity 'ENDEMIC' named entity 'MOTHERS' named entity 'INFANTS' named entity 'ELISAS' named entity '14 WEEKS' named entity 'HUMAN' named entity 'IGG' named entity 'REPEATED' named entity 'RHESUS ROTAVIRUS VACCINE' named entity 'CONTROL' named entity 'VACCINATION' named entity 'ROTAVIRUS' named entity 'IGA' named entity 'VACCINATION' named entity 'IGG' named entity 'ROTAVIRUS IGA' named entity 'NEUTRALISING ANTIBODIES' named entity 'INCREASES' named entity 'BABOON' named entity 'SAMPLES' named entity 'SERUM' named entity 'L-2' named entity 'MILK' named entity 'PRODUCING' named entity 'VACCINATED' named entity 'MAY BE' named entity 'INCREASING' named entity 'ADJUVANTED' named entity 'PARTURITION' named entity 'TESTS' named entity 'SAMPLED' named entity 'HAVE' named entity 'BABOON' named entity 'STIMULATION' named entity 'MILK' named entity 'LEVEL' covid:arg/b48c350f6d3b7087b3260e04b26f8db5ca3bc214 named entity 'antibodies' named entity 'antibodies' named entity 'weekly'

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