About: Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study

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About: Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study
Creator	De Luca, Daniele Piastra, Marco Chidini, Giovanna Conti, Giorgio Costa, Roberta Ferrone, Giuliano Spinazzola, Giorgia
Source	PMC
abstract	BACKGROUND: Neurally adjusted ventilatory assist (NAVA) is an innovative mode for assisted ventilation that improves patient-ventilator interaction in children. The aim of this study was to assess the effects of patient-ventilator interaction comparing NAVA with pressure support ventilation (PSV) in patients difficult to wean from mechanical ventilation after moderate pediatric acute respiratory distress syndrome (PARDS). METHODS: In this physiological crossover study, 12 patients admitted in the Pediatric Intensive Care Unit (PICU) with moderate PARDS failing up to 3 spontaneous breathing trials in less than 7 days, were enrolled. Patients underwent three study conditions lasting 1 h each: PSV1, NAVA and PSV2. RESULTS: The Asynchrony Index (AI) was significantly reduced during the NAVA trial compared to both the PSV1 and PSV2 trials (p = 0.001). During the NAVA trial, the inspiratory and expiratory trigger delays were significantly shorter compared to those obtained during PSV1 and PSV2 trials (Delay(trinsp)p < 0.001, Delay(trexp)p = 0.013). These results explain the significantly longer Time(sync) observed during the NAVA trial (p < 0.001). In terms of gas exchanges, PaO(2) value significantly improved in the NAVA trial with respect to the PSV trials (p < 0.02). The PaO(2)/FiO(2) ratio showed a significant improvement during the NAVA trial compared to both the PSV1 and PSV2 trials (p = 0.004). CONCLUSIONS: In this specific PICU population, presenting difficulty in weaning after PARDS, NAVA was associated with a reduction of the AI and a significant improvement in oxygenation compared to PSV mode. TRIAL REGISTRATION: ClinicalTrial.gov Identifier: NCT04360590 “Retrospectively registered”.
has issue date	2020-07-07(xsd:dateTime)
bibo:doi	10.1186/s12887-020-02227-1
has license	cc-by
sha1sum (hex)	b49f1745c1b4b1b1aba6e54dd0788442f2b63a9d
schema:url	https://doi.org/10.1186/s12887-020-02227-1
resource representing a document's title	Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study
has PubMed Central identifier	PMC7338290
schema:publication	BMC Pediatr
resource representing a document's body	covid:b49f1745c1b4b1b1aba6e54dd0788442f2b63a9d#body_text
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