About: Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

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About: Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Creator	Gudi, Viktoria Stangel, Martin Gingele, Stefan Skripuletz, Thomas Hermann, Dirk Weissert, Robert
Source	PMC
abstract	Although astrogliosis and microglia activation are characteristic features of multiple sclerosis (MS) and other central nervous system (CNS) lesions the exact functions of these events are not fully understood. Animal models help to understand the complex interplay between the different cell types of the CNS and uncover general mechanisms of damage and repair of myelin sheaths. The so called cuprizone model is a toxic model of demyelination in the CNS white and gray matter, which lacks an autoimmune component. Cuprizone induces apoptosis of mature oligodendrocytes that leads to a robust demyelination and profound activation of both astrocytes and microglia with regional heterogeneity between different white and gray matter regions. Although not suitable to study autoimmune mediated demyelination, this model is extremely helpful to elucidate basic cellular and molecular mechanisms during de- and particularly remyelination independently of interactions with peripheral immune cells. Phagocytosis and removal of damaged myelin seems to be one of the major roles of microglia in this model and it is well known that removal of myelin debris is a prerequisite of successful remyelination. Furthermore, microglia provide several signals that support remyelination. The role of astrocytes during de- and remyelination is not well defined. Both supportive and destructive functions have been suggested. Using the cuprizone model we could demonstrate that there is an important crosstalk between astrocytes and microglia. In this review we focus on the role of glial reactions and interaction in the cuprizone model. Advantages and limitations of as well as its potential therapeutic relevance for the human disease MS are critically discussed in comparison to other animal models.
has issue date	2014-03-13(xsd:dateTime)
bibo:doi	10.3389/fncel.2014.00073
bibo:pmid	24659953
has license	cc-by
sha1sum (hex)	b4b8196a56fe00d653d288226f12952824c5b7cc
schema:url	https://doi.org/10.3389/fncel.2014.00073
resource representing a document's title	Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
has PubMed Central identifier	PMC3952085
has PubMed identifier	24659953
schema:publication	Front Cell Neurosci
resource representing a document's body	covid:b4b8196a56fe00d653d288226f12952824c5b7cc#body_text
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