About: The inflamed sputum in lower respiratory tract infection: l‐lactate levels are correlated to neutrophil accumulation

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About: The inflamed sputum in lower respiratory tract infection: l‐lactate levels are correlated to neutrophil accumulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The inflamed sputum in lower respiratory tract infection: l‐lactate levels are correlated to neutrophil accumulation
Creator	Jensen, Andreas Petersen, Pelle Fredman, Gabriella Hertz, Frederik Kolpen, Mette Ravn, Pernille Av, Jensen Baunbaek-Egelund, Gertrud Faurholt-Jepsen, Daniel Fb, Hertz Pt, Petersen Pø, Jensen
source	PMC
abstract	Lower respiratory tract infections (LRTI) are common, but little is known about the response of biomarkers of inflammation in the lungs. Therefore, our primary aim was to compare the concentration of l‐lactate to the concentration of neutrophils in sputum and systemic markers of infection. Because it is difficult to differentiate viral and bacterial infection on the basis of clinical presentation in LRTI, our secondary aim was to evaluate if l‐ and d‐lactate may serve as markers of local inflammation as representatives of neutrophils and bacteria, respectively. METHODS: Patients with acute LRTI were prospectively recruited. Sputum samples were collected and analysed for neutrophil count, l‐lactate and d‐lactate. We had data on pathogens from sputum cultures and polymerase chain reaction (PCR) (atypical bacteria, virus) and C‐reactive protein (CRP) from blood. RESULTS: In 44 sputum samples from 32 patients, the median (interquartile range (IQR)) sputum neutrophil granulocyte count was 0.615 × 10(7) cells/mL (0.236–1.575). The sputum neutrophil granulocyte count was associated with sputum l‐lactate (p = 0.011) and CRP (p = 0.018), but not with d‐lactate (p = 0.177). There was a strong association between sputum d‐lactate and l‐lactate (p < 0.0001). CONCLUSION: As l‐lactate in sputum is closely correlated to sequestration of neutrophils in the lungs, l‐lactate is a marker for local inflammation in LRTI and a potential biomarker in clinical management of LRTI. On expectorated sputum, d‐lactate had no clinical relevance.
has issue date	2019-01-06(xsd:dateTime)
bibo:doi	10.1111/apm.12913
bibo:pmid	30614067
has license	no-cc
sha1sum (hex)	b4f730028f2322aa3828771bca1dadec52a86f02
schema:url	https://doi.org/10.1111/apm.12913
resource representing a document's title	The inflamed sputum in lower respiratory tract infection: l‐lactate levels are correlated to neutrophil accumulation
has PubMed Central identifier	PMC7159756
has PubMed identifier	30614067
schema:publication	APMIS
resource representing a document's body	covid:b4f730028f2322aa3828771bca1dadec52a86f02#body_text
is schema:about of	named entity 'collected' named entity 'systemic' named entity 'evaluate' named entity 'correlated' named entity 'biomarker' named entity 'common' named entity 'respiratory tract infections' named entity 'Because' named entity 'pathogens' named entity 'correlated' named entity 'L-lactate' named entity 'neutrophil' named entity 'infection' named entity 'AIM' named entity 'BACTERIA' named entity 'CLINICAL PRESENTATION' named entity 'OUR' named entity 'SECONDARY' named entity 'MARKER' named entity 'LRTI' named entity 'C-REACTIVE PROTEIN' named entity 'KNOWN' named entity 'CLINICAL RELEVANCE' named entity 'neutrophil granulocyte' named entity 'sputum' named entity 'basis' named entity 'presentation' named entity 'Therefore' named entity 'inflammation' named entity 'There' named entity 'L-lactate' named entity 'bacteria' named entity 'Methods' named entity 'concentration' named entity 'potential' named entity 'differentiate' named entity 'compare' named entity 'neutrophil' named entity 'CRP' named entity 'sputum' named entity 'accumulation' named entity 'sputum' named entity 'L-lactate' named entity 'sputum' named entity 'CRP' named entity 'LRTI' named entity 'LRTI' named entity 'sputum' named entity 'inflammation' named entity 'Sputum' named entity 'virus' named entity 'sputum' named entity 'neutrophil' named entity 'lower respiratory tract infection' named entity 'L-lactate' named entity 'emergency ward' named entity 'non-normally distributed' named entity 'CD45' named entity 'antibiotics' named entity 'Influenza' named entity 'heart rate' named entity 'D-lactate' named entity 'lactate' named entity 'neutrophil' named entity 'lactate' named entity 'inflammation' named entity 'LRTI' named entity 'sputum' named entity 'neutrophil' named entity 'pathogens'

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