About: COVID-19 in Spain: age, Interleukin-6, C Reactive Protein and lymphocytes as key clues from a multicentre retrospective study

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About: COVID-19 in Spain: age, Interleukin-6, C Reactive Protein and lymphocytes as key clues from a multicentre retrospective study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 in Spain: age, Interleukin-6, C Reactive Protein and lymphocytes as key clues from a multicentre retrospective study
Creator	Martín, María López-Hoyos, Marcos Marco, Francisco Martínez, Eva Abad-Molina, Cristina Molina, Juan Yarce, Oscar Aguilar, Marta Almeida, Delia Boix, Francisco Cantenys, Sergi Cunill, Vanesa Fernández, Luis Gil, Juana González-Martínez, Gema Hernández, Manuel Jiménez, Yesenia Jurado, Aurora Martínez, Alba Martínez-Saavedra, María Medina, Silvia Melero, Josefa Monzón, David Mora, Sergio Navas, Ana Ocaña, Esther Ocejo-Vinyals, Gonzalo Ontañón, Jesús Orduña, Antonio Perurena-Prieto, Janire Prada, Álvaro Quirant, Bibiana Rodríguez, Beatriz Rojo, Ricardo Trujillo, Antonio Vegas, María Vergara, Esther
Source	MedRxiv
abstract	SARS-CoV-2 infection has widely spread to the hugest public health challenge to date, COVID-19 pandemic. Different fatality rates among countries are probably due to unstandardized records being carried out by local health authorities. Spanish case-fatality rate is 11.86%, far higher to those reported in Asia or by other European countries. A multicenter retrospective study of demographic, clinical, laboratory and immunological features of 574 Spanish COVID-19 inpatients (59.4% males) and their outcomes was performed. 27.7% cases presented a mild curse, 42% a moderate one and 30.3%, severe. Ages ranged from 18 to 98 (average 63.2). Interleukin 6 was higher as increasing severity. On the other hand, CD8 lymphocyte count was significantly lower as severity grew and subpopulations CD4, CD8, CD19 and NK showed concordant lowering trends. Severity-related natural killer percent descents were evidenced just within aged cases. A significant severity-related decrease of CD4 lymphocytes was found in males. The use of renin-angiotensin system blockers was associated with moderate or mild disease courses. Clinical course of the disease is more severe in this study than in previous literature cohorts. Age and age-related comorbidities, such as dyslipidemia, hypertension or diabetes, were also higher. Immunosenescence might be therefore a suitable explanation for immune system effectors severity-related hampering. Adaptive immunity would go exhausted and a huge ineffective and almost deleterious innate response would account for COVID-19 severity. Hypertensive patients treated with renin-angiotensin system blockers developed milder forms of the disease.
has issue date	2020-05-16(xsd:dateTime)
bibo:doi	10.1101/2020.05.13.20101345
has license	medrxiv
sha1sum (hex)	b4fed9f9b5a6480c629befac0d2be3f76b9150c5
schema:url	https://doi.org/10.1101/2020.05.13.20101345
resource representing a document's title	COVID-19 in Spain: age, Interleukin-6, C Reactive Protein and lymphocytes as key clues from a multicentre retrospective study
resource representing a document's body	covid:b4fed9f9b5a6480c629befac0d2be3f76b9150c5#body_text
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