About: Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics

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About: Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics
Creator	Chen, Yu Choi, Eunjin Bao, Xiaoyong Ren, Yuping Zhang, Ke Deng, Xiaoling Ye, Sha Zhang, Kangling
Source	PMC
abstract	Human metapneumovirus (hMPV) is a leading cause of lower respiratory infection in pediatric populations globally. This study examined proteomic profile changes in A549 cells infected with hMPV and two attenuated mutants with deleted PDZ domain-binding motif(s) in the M2-2 protein. These motifs are involved in the interruption of antiviral signaling, namely the interaction between the TNF receptor associated factor (TRAF) and mitochondrial antiviral-signaling (MAVS) proteins. The aim of this study was to provide insight into the overall and novel impact of M2-2 motifs on cellular responses via an unbiased comparison. Tandem mass tagging, stable isotope labeling, and high-resolution mass spectrometry were used for quantitative proteomic analysis. Using quantitative proteomics and Venn analysis, 1248 common proteins were detected in all infected samples of both technical sets. Hierarchical clustering of the differentiated proteome displayed distinct proteomic signatures that were controlled by the motif(s). Bioinformatics and experimental analysis confirmed the differentiated proteomes, revealed novel cellular biological events, and implicated key pathways controlled by hMPV M2-2 PDZ domain-binding motif(s). This provides further insight for evaluating M2-2 mutants as potent vaccine candidates.
has issue date	2017-12-03(xsd:dateTime)
bibo:doi	10.3390/vaccines5040045
bibo:pmid	29207503
has license	cc-by
sha1sum (hex)	b5464879315d206d3053d3cfbba9b3d914e8b709
schema:url	https://doi.org/10.3390/vaccines5040045
resource representing a document's title	Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics
has PubMed Central identifier	PMC5748611
has PubMed identifier	29207503
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:b5464879315d206d3053d3cfbba9b3d914e8b709#body_text
is schema:about of	named entity 'CHANGES' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'DETECTION' named entity 'PROTEOMICS' named entity 'USING' named entity '1248' named entity 'HIGH-RESOLUTION MASS SPECTROMETRY' named entity 'EVENTS' named entity 'CONFIRMED' named entity 'EVALUATING' named entity 'ANALYSIS' named entity 'OVERALL' named entity 'BINDING' named entity 'PATHWAYS' named entity 'LOWER RESPIRATORY INFECTION' named entity 'QUANTITATIVE' named entity 'PROTEOMES' named entity 'AIM' named entity 'DIFFERENTIATED' named entity 'COMMON' named entity 'ASSOCIATED' named entity 'IS A' named entity 'THESE' named entity '28S' named entity 'TANDEM' named entity 'TAGGING' named entity 'PROVIDES' named entity 'STUDY' named entity 'INTERRUPTION' named entity 'MOTIF' named entity 'A549 CELLS' named entity 'M2-2' named entity 'PROTEIN ' named entity 'DISTINCT' named entity 'LEADING' named entity 'QUANTITATIVE PROTEOMICS' named entity 'USING' named entity 'SIGNATURES' named entity 'MUTANTS' named entity 'CONTROLLED BY' named entity 'PEDIATRIC' named entity 'M2-2' named entity 'REVEALED' named entity 'MASS' named entity 'USED' named entity 'INVOLVED' named entity 'RESPONSES' named entity 'PDZ DOMAIN' named entity 'CAUSE' named entity 'INTERACTION' named entity 'MITOCHONDRIAL' named entity 'ANTIVIRAL' named entity 'CHANGES' named entity 'PROTEOMIC ANALYSIS' named entity 'VACCINE' named entity 'TECHNICAL' named entity 'CELLULAR' named entity 'BIOLOGICAL' named entity 'EXAMINED' named entity 'TNF RECEPTOR' named entity 'SAMPLES' named entity 'PROTEOMIC PROFILE' named entity 'ATTENUATED' named entity 'NOVEL' named entity 'PROTEOMIC' named entity 'DELETED' named entity 'POPULATIONS' named entity 'ISOTOPE LABELING' named entity 'PROTEOME' named entity 'EXPERIMENTAL' named entity 'TO PROVIDE' named entity 'KEY' named entity 'INSIGHT' named entity 'QUANTITATIVE'

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