About: Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense

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About: Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense
Creator	Cox, Eric Capobianco, Daniela Cutone, Antimo Mastromarino, Paola Paesano, Rosalba Rosa, Luigi Schiavi, Elisa Valenti, Piera Lepanto, Maria Jarvis, Gary Wright, Atte
Source	Medline; PMC
abstract	The innate defense system of the female mucosal genital tract involves a close and complex interaction among the healthy vaginal microbiota, different cells, and various proteins that protect the host from pathogens. Vaginal lactobacilli and lactoferrin represent two essential actors in the vaginal environment. Lactobacilli represent the dominant bacterial species able to prevent facultative and obligate anaerobes outnumber in vaginal microbiota maintaining healthy microbial homeostasis. Several mechanisms underlie the protection exerted by lactobacilli: competition for nutrients and tissue adherence, reduction of the vaginal pH, modulation of immunity, and production of bioactive compounds. Among bioactive factors of cervicovaginal mucosa, lactoferrin, an iron-binding cationic glycoprotein, is a multifunctional glycoprotein with antibacterial, antifungal, antiviral, and antiparasitic activities, recently emerging as an important modulator of inflammation. Lactobacilli and lactoferrin are largely under the influence of female hormones and of paracrine production of various cytokines. Lactoferrin is strongly increased in lower genital tract mucosal fluid of women affected by Neisseria gonorrheae, Chlamydia trachomatis, and Trichomonas vaginalis infections promoting both innate and adaptive immune responses. In vaginal dysbiosis characterized by low amounts of vaginal lactobacilli and increased levels of endogenous anaerobic bacteria, the increase in lactoferrin could act as an immune modulator assuming the role normally played by the healthy microbiota in vaginal mucosa. Then lactoferrin and lactobacilli may be considered as biomarkers of altered microbial homeostasis at vaginal level. Considering the shortage of effective treatments to counteract recurrent and/or antibiotic-resistant bacterial infections, the intravaginal administration of lactobacilli and lactoferrin could be a novel efficient therapeutic strategy and a valuable tool to restore mucosal immune homeostasis.
has issue date	2018-03-01(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.00376
bibo:pmid	29545798
has license	cc-by
sha1sum (hex)	b5535ddf603f7b3b78897553296917cad0c0a789
schema:url	https://doi.org/10.3389/fimmu.2018.00376
resource representing a document's title	Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense
has PubMed Central identifier	PMC5837981
has PubMed identifier	29545798
schema:publication	Front Immunol
resource representing a document's body	covid:b5535ddf603f7b3b78897553296917cad0c0a789#body_text
is schema:about of	named entity 'Chlamydia trachomatis' named entity 'lactoferrin' named entity 'obligate' named entity 'cells' named entity 'anaerobic bacteria' named entity 'antiviral' named entity 'anaerobes' named entity 'lactobacilli' named entity 'modulator' named entity 'ROLE' named entity 'GLYCOPROTEIN' named entity 'CYTOKINES' covid:arg/b5535ddf603f7b3b78897553296917cad0c0a789 named entity 'MUCOSAL' named entity 'ESSENTIAL' named entity 'THERAPEUTIC' named entity 'LACTOFERRIN' named entity 'MUCOSA' named entity 'LEVELS' named entity 'BACTERIAL' named entity 'RECENTLY' named entity 'PRODUCTION' named entity 'PARACRINE' named entity 'FEMALE' named entity 'ENDOGENOUS' named entity 'EFFECTIVE' named entity 'DEFENSE' named entity 'INTRAVAGINAL ADMINISTRATION' named entity 'IMPORTANT' named entity 'LACTOFERRIN' named entity 'ADAPTIVE IMMUNE RESPONSES' named entity 'INTERACTION' named entity 'HORMONES' named entity 'RESISTANT' named entity 'NEISSERIA GONORRHEAE' named entity 'PROMOTING' named entity 'AMOUNTS' named entity 'PLAYED' named entity 'EXERTED' named entity 'CHARACTERIZED' named entity 'MODULATION' named entity 'ANTIFUNGAL' named entity 'NUTRIENTS' named entity 'ROLE' named entity 'DEFENSE' named entity 'CELLS' named entity 'RECURRENT' named entity 'HEALTHY' named entity 'VAGINAL' named entity 'MUCOSAL' named entity 'ALTERED' named entity 'TRICHOMONAS VAGINALIS' named entity 'BINDING' named entity 'LOWER' named entity 'NOVEL' named entity 'MICROBIAL' named entity 'DOMINANT' named entity 'ACTIVITIES' named entity 'ACT' named entity 'MODULATOR' named entity 'AFFECTED' named entity 'DIFFERENT' named entity 'COMPETITION' named entity 'ANTIVIRAL' named entity 'ADHERENCE' named entity 'CHLAMYDIA TRACHOMATIS' named entity 'INCREASE' named entity 'ACTORS' named entity 'VARIOUS' named entity 'REPRESENT' named entity 'FLUID'

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