About: Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis

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About: Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis
Creator	Feng, Li Chen, Jianfei Shi, Da Shi, Hongyan Zhang, Xin Xue, Mei Cao, Liyan Liu, Jianbo Huang, Liping Liu, Changming Wei, Yanwu
Source	Elsevier; Medline; PMC
abstract	Abstract Endoplasmic reticulum (ER) stress is associated with numerous mammalian diseases, especially viral diseases. Porcine parvovirus (PPV) is the causative agent of reproductive failure in swine. Here, we observed that the PPV infection of porcine kidney 15 and porcine testis cells resulted in the activation of ER stress sensors mediated by protein kinase R-like ER kinase (PERK), but not inositol-requiring enzyme 1 and activating transcription factor 6 (ATF6). ER stress activation obviously blocked PPV replication. Depletion of proteins, such as PERK, eukaryotic initiation factor 2, and ATF4, by small interfering RNA significantly enhanced PPV replication. Moreover, the pro-apoptotic factor C/EBP homologous protein was identified a key factor in the inhibition of PPV replication. These data demonstrate that PPV infection activates ER stress through the PERK signaling pathway and that ER stress inhibits further PPV replication by promoting apoptosis.
has issue date	2020-01-02(xsd:dateTime)
bibo:doi	10.1016/j.virol.2019.09.012
bibo:pmid	31605941
has license	els-covid
sha1sum (hex)	b55715b8d1dea109472c99d8db045e9bd718c90a
schema:url	https://doi.org/10.1016/j.virol.2019.09.012
resource representing a document's title	Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis
has PubMed Central identifier	PMC7127029
has PubMed identifier	31605941
schema:publication	Virology
resource representing a document's body	covid:b55715b8d1dea109472c99d8db045e9bd718c90a#body_text
is schema:about of	named entity 'ATF4' named entity 'PRO-' named entity 'INOSITOL-REQUIRING ENZYME 1' named entity 'PERK' named entity 'THESE' named entity 'STRESS' named entity 'BUT' named entity 'MEDIATED' named entity 'S T' named entity 'ACTIVATING TRANSCRIPTION FACTOR 6' named entity 'FACTOR C' named entity 'PROMOTING' named entity 'REPLICATION' named entity 'SENSORS' named entity 'APOPTOTIC' named entity 'SMALL INTERFERING RNA' named entity 'SIGNALING PATHWAY' named entity 'ENHANCED' named entity 'replication' named entity 'enhanced' named entity 'PPV' named entity 'PPV' named entity 'promoting' named entity 'blocked' named entity 'ER stress' named entity 'replication' named entity 'PERK' named entity 'ACTIVATION' covid:arg/b55715b8d1dea109472c99d8db045e9bd718c90a named entity 'SIGNALING PATHWAY' named entity 'PORCINE' named entity 'DATA' named entity 'PROTEINS' named entity 'DISEASES' named entity 'FACTOR' named entity 'SUPPRESSED' named entity 'REPLICATION' named entity 'DEPLETION' named entity 'TESTIS' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'PATHWAY' named entity 'PROTEIN KINASE R' named entity 'CELLS' named entity 'ACTIVATION' named entity 'ENDOPLASMIC RETICULUM STRESS' named entity 'PERK' named entity 'MEDIATED' named entity 'ENDOPLASMIC RETICULUM STRESS' named entity 'PORCINE PARVOVIRUS' named entity 'PPV' named entity 'EUKARYOTIC INITIATION FACTOR 2' named entity 'IDENTIFIED' named entity 'HERE' named entity 'HOMOLOGOUS PROTEIN' named entity 'PORCINE PARVOVIRUS' named entity 'KEY' named entity 'INHIBITION' named entity 'ASSOCIATED WITH' named entity 'APOPTOTIC CELL DEATH' named entity 'ER STRESS' named entity 'APOPTOSIS' named entity 'ACTIVATES' named entity 'ENDOPLASMIC RETICULUM' named entity 'MAMMALIAN' named entity 'VIRAL DISEASES' named entity 'NUMEROUS' named entity 'OBSERVED' named entity 'LIKE' named entity 'KINASE' named entity 'CAUSATIVE AGENT' named entity 'REPRODUCTIVE FAILURE'

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