About: Development of an Aerosol Model of Cryptococcus Reveals Humidity as an Important Factor Affecting the Viability of Cryptococcus during Aerosolization

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About: Development of an Aerosol Model of Cryptococcus Reveals Humidity as an Important Factor Affecting the Viability of Cryptococcus during Aerosolization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of an Aerosol Model of Cryptococcus Reveals Humidity as an Important Factor Affecting the Viability of Cryptococcus during Aerosolization
Creator	Frothingham, Richard Saini, Divey Heitman, Joseph Byrnes, Edmond Springer, Deborah
Source	PMC
abstract	Cryptococcus is an emerging global health threat that is annually responsible for over 1,000,000 infections and one third of all AIDS patient deaths. There is an ongoing outbreak of cryptococcosis in the western United States and Canada. Cryptococcosis is a disease resulting from the inhalation of the infectious propagules from the environment. The current and most frequently used animal infection models initiate infection via liquid suspension through intranasal instillation or intravenous injection. These models do not replicate the typically dry nature of aerosol exposure and may hinder our ability to decipher the initial events that lead to clearance or the establishment of infection. We have established a standardized aerosol model of murine infection for the human fungal pathogen Cryptococcus. Aerosolized cells were generated utilizing a Collison nebulizer in a whole-body Madison Chamber at different humidity conditions. The aerosols inside the chamber were sampled using a BioSampler to determine viable aerosol concentration and spray factor (ratio of viable aerosol concentration to total inoculum concentration). We have effectively delivered yeast and yeast-spore mixtures to the lungs of mice and observed the establishment of disease. We observed that growth conditions prior to exposure and humidity within the Madison Chamber during exposure can alter Cryptococcus survival and dose retained in mice.
has issue date	2013-07-23(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0069804
bibo:pmid	23894542
has license	cc-by
sha1sum (hex)	b59b58c13370a390a58c6cd79e61f97bf9bee37d
schema:url	https://doi.org/10.1371/journal.pone.0069804
resource representing a document's title	Development of an Aerosol Model of Cryptococcus Reveals Humidity as an Important Factor Affecting the Viability of Cryptococcus during Aerosolization
has PubMed Central identifier	PMC3720958
has PubMed identifier	23894542
schema:publication	PLoS One
resource representing a document's body	covid:b59b58c13370a390a58c6cd79e61f97bf9bee37d#body_text
is schema:about of	named entity 'viable' named entity 'lungs' named entity 'Chamber' named entity 'global health' named entity 'cryptococcosis' named entity 'Cryptococcus' named entity 'concentration' named entity 'Cryptococcus' named entity 'effectively' named entity 'These' named entity 'aerosol' named entity 'VIABLE' named entity 'INTRAVENOUS INJECTION' named entity 'EVENTS' named entity 'ANIMAL' named entity 'IMPORTANT' named entity 'CELLS' named entity 'INOCULUM' named entity 'TO EXPOSURE' named entity 'ANNUALLY' named entity 'INSIDE' named entity 'CONDITIONS' named entity 'RESPONSIBLE' named entity 'DOSE' named entity 'GLOBAL HEALTH' named entity 'AEROSOLS' named entity 'CLEARANCE' named entity 'USED' named entity 'SAMPLED' named entity 'INITIAL' named entity 'ESTABLISHMENT' named entity 'CRYPTOCOCCOSIS' named entity 'INFECTION' named entity 'ALTER' named entity 'BODY' named entity 'MODEL OF' named entity 'DEVELOPMENT' named entity 'HUMIDITY' named entity 'FACTOR' named entity 'NEBULIZER' named entity 'DECIPHER' named entity 'ESTABLISHED' named entity 'SURVIVAL' named entity 'WESTERN' named entity 'LIQUID' named entity 'TOTAL' named entity 'AEROSOL' named entity 'CRYPTOCOCCUS' named entity 'AFFECTING' named entity 'VIABILITY' named entity 'CRYPTOCOCCUS' named entity 'HAVE' named entity 'HUMIDITY' named entity 'IS A' named entity 'INFECTIONS' named entity 'DIFFERENT' named entity 'ONGOING' named entity 'CURRENT' named entity 'THE LUNGS' named entity 'UNITED STATES' named entity 'MODEL OF' named entity 'DO NOT' named entity 'DRY' named entity 'HUMAN' named entity 'REPLICATE' named entity 'MICE' named entity 'CITATION' named entity 'DEATHS' named entity 'FUNGAL PATHOGEN' named entity 'INITIATE' named entity 'LEAD' named entity 'GROWTH' named entity 'MADISON' named entity 'CHAMBER' named entity 'ENVIRONMENT' named entity 'OUR' named entity 'SPRINGER'

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