About: Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease

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About: Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease
Creator	Allez, Matthieu Brousse, Nicole Cellier, Christophe Cerf-Bensussan, Nadine Jian, Raymond Vivier, Eric Carvalho, Carla Colombel, Jean-Fréderic Cugnenc, Henri Desreumaux, Pierre Ebert, Ellen Evans, Kelly Gache, Cécile Guy-Grand, Delphine Jabri, Bana Lopez-Botet, Miguel Matuchansky, Claude Moretta, Alessandro Mougenot, Jean-Franç Ois Patey-Mariaud, Natacha Roberts, Arthur Schmitz, Jacques Serre, D
source	Elsevier; Medline; PMC
abstract	Abstract Background & Aims: Celiac disease is a gluten-induced enteropathy characterized by the presence of gliadin-specific CD4+ T cells in the lamina propria and by a prominent intraepithelial T-cell infiltration of unknown mechanism. The aim of this study was to characterize the subset(s) of intraepithelial lymphocytes (IELs) expanding during active celiac disease to provide insights into the mechanisms involved in their expansion. Methods: Flow-cytometric analysis of isolated IELs and/or immunohistochemical staining of frozen sections were performed in 51 celiac patients and 50 controls with a panel of monoclonal antibodies against T-cell and natural killer (NK) receptors. In addition, in vitro studies were performed to identify candidate stimuli for NK receptor expression. Results: In normal intestine, different proportions of IELs, which were mainly T cells, expressed the NK receptors CD94/NKG2, NKR-P1A, KIR2D/3D, NKp46, Pen5, or CD56. During the active phase of celiac disease, the frequency of CD94+ IELs, which were mostly αβ T cells, was conspicuously increased over controls. In contrast, the expression of other NK markers was not modified. Furthermore, expression of CD94 could be selectively induced in vitro by T-cell receptor activation and/or interleukin 15, a cytokine produced by intestinal epithelial cells. Conclusions: The gut epithelium favors the development of T cells that express NK receptors. In active celiac disease, there is a specific and selective increase of IELs expressing CD94, the HLA-E–specific NK receptor that may be related to T-cell receptor activation and/or interleukin 15 secretion. GASTROENTEROLOGY 2000;118:867-879
has issue date	2000-05-31(xsd:dateTime)
bibo:doi	10.1016/s0016-5085(00)70173-9
bibo:pmid	10784586
has license	els-covid
sha1sum (hex)	b5e09d77c6f82fa8a6786279db3fa92085fa4b65
schema:url	https://doi.org/10.1016/s0016-5085%2800%2970173-9
resource representing a document's title	Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease
has PubMed Central identifier	PMC7095198
has PubMed identifier	10784586
schema:publication	Gastroenterology
resource representing a document's body	covid:b5e09d77c6f82fa8a6786279db3fa92085fa4b65#body_text
is schema:about of	named entity 'development' named entity 'performed' named entity 'CD94' named entity 'Methods' named entity 'CD56' named entity 'performed' named entity 'Expansion' named entity 'CONTROLS' named entity 'ADDITION' named entity 'SELECTIVE' named entity 'INVOLVED' named entity 'RELATED' named entity 'CD56' named entity 'CELL INFILTRATION ' named entity 'RECEPTOR EXPRESSION' named entity 'CONCLUSIONS' named entity 'T CELLS' named entity 'STIMULI' named entity 'IMMUNOHISTOCHEMICAL STAINING' named entity 'INTESTINAL' named entity 'MARKERS' named entity 'LAMINA PROPRIA' named entity 'NKR-P1A' named entity 'GUT EPITHELIUM' named entity 'PHASE' named entity 'CELIAC DISEASE' named entity 'NKP46' named entity 'INCREASE' named entity 'EXPRESS' named entity 'CD4' named entity 'AIMS' named entity 'EXPRESSION' named entity 'INTESTINE' named entity 'INSIGHTS' named entity 'THE GUT' named entity 'CONTRAST' named entity 'DEVELOPMENT' named entity 'EXPRESSED' named entity 'T-CELL RECEPTOR ACTIVATION' named entity 'CELIAC' named entity 'T-CELL' named entity 'CANDIDATE' named entity 'AIM' named entity 'FLOW' named entity 'PANEL' named entity 'THEIR' named entity 'TO CHARACTERIZE' named entity 'EXPANSION' named entity 'CD94' named entity 'METHODS' named entity 'IS A' named entity 'TO PROVIDE' named entity 'INTRAEPITHELIAL LYMPHOCYTES' named entity 'SPECIFIC' named entity 'HLA-E' named entity 'SELECTIVE' named entity 'CELIAC DISEASE' named entity 'TO IDENTIFY' named entity 'IN VITRO'

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