About: Liver Injury in Critically Ill and Non-critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Liver Injury in Critically Ill and Non-critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study
Creator	Li, Lu Li, Wang Kozlakidis, Zisis Chen, Na Liang, Tingbo Qiu, Yunqing Xie, Y Hu, Yunzhen Jiang, Saiping Lu, Xiaoyang Miao, Jing Rao, Yuefeng Ru, Renping Wang, Rongrong Wu, Xiuhua Xie, Minghua Ye, Ziqi Zuo, Minjuan Zhang, Lingli Dongsheng, Hong Hu, Ye Khurana, Sandeep Liang, Qiu
source	Medline; PMC
abstract	Background: Liver injury commonly occurs in patients with COVID-19. There is limited data describing the course of liver injury occurrence in patients with different disease severity, and the causes and risk factors are unknown. We aim to investigate the incidence, characteristics, risk factors, and clinical outcomes of liver injury in patients with COVID-19. Methods: This retrospective observational study was conducted in three hospitals (Zhejiang, China). From January 19, 2020 to February 20, 2020, patients confirmed with COVID-19 (≥18 years) and without liver injury were enrolled and divided into non-critically ill and critically ill groups. The incidence and characteristics of liver injury were compared between the two groups. Demographics, clinical characteristics, treatments, and treatment outcomes between patients with or without liver injury were compared within each group. The multivariable logistic regression model was used to explore the risk factors for liver injury. Results: The mean age of 131 enrolled patients was 51.2 years (standard deviation [SD]: 16.1 years), and 70 (53.4%) patients were male. A total of 76 patients developed liver injury (mild, 40.5%; moderate, 15.3%; severe, 2.3%) with a median occurrence time of 10.0 days. Critically ill patients had higher and earlier occurrence (81.5 vs. 51.9%, 12.0 vs. 5.0 days; p < 0.001), greater injury severity (p < 0.001), and slower recovery (50.0 vs. 61.1%) of liver function than non-critically ill patients. Multivariable regression showed that the number of concomitant medications (odds ratio [OR]: 1.12, 95% confidence interval [CI]: 1.05–1.21) and the combination treatment of lopinavir/ritonavir and arbidol (OR: 3.58, 95% CI: 1.44–9.52) were risk factors for liver injury in non-critically ill patients. The metabolism of arbidol can be significantly inhibited by lopinavir/ritonavir in vitro (p < 0.005), which may be the underlying cause of drug-related liver injury. Liver injury was related to increased length of hospital stay (mean difference [MD]: 3.2, 95% CI: 1.3–5.2) and viral shedding duration (MD: 3.0, 95% CI: 1.0–4.9). Conclusions: Critically ill patients with COVID-19 suffered earlier occurrence, greater injury severity, and slower recovery from liver injury than non-critically ill patients. Drug factors were related to liver injury in non-critically ill patients. Liver injury was related to prolonged hospital stay and viral shedding duration in patients with COVID-19. Clinical Trial Registration: World Health Organization International Clinical Trials Registry Platform, ChiCTR2000030593. Registered March 8, 2020.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.3389/fmed.2020.00347
bibo:pmid	32656222
has license	cc-by
sha1sum (hex)	b5f185fcc710eacf01c0f7ff954be7b3d9770249
schema:url	https://doi.org/10.3389/fmed.2020.00347
resource representing a document's title	Liver Injury in Critically Ill and Non-critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study
has PubMed Central identifier	PMC7324794
has PubMed identifier	32656222
schema:publication	Front Med (Lausanne)
resource representing a document's body	covid:b5f185fcc710eacf01c0f7ff954be7b3d9770249#body_text
is schema:about of	named entity 'TO INVESTIGATE' named entity 'CLINICAL OUTCOMES' named entity 'Liver injury' named entity 'risk factors' named entity 'COVID-19' named entity 'risk factors' named entity 'Clinical Trials Registry' named entity 'China' named entity 'clinical symptoms' named entity 'pregnancy' named entity 'non-steroidal anti-inflammatory drugs' named entity 'CYP3A' named entity 'log-rank test' named entity 'critically ill patients' named entity 'SARS-CoV-2' named entity 'antiviral agents' named entity 'COVID-19' named entity 'pathogenesis' named entity 'risk factors' named entity 'arbidol' named entity 'cerebrovascular diseases' named entity 'critically ill' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'concomitant drugs' named entity 'liver' named entity 'critically ill' named entity '5.0' named entity 'adverse reactions' named entity 'cholangiocytes' named entity 'COVID-19' named entity 'liver injury' named entity 'liver injury' named entity 'clinical outcome' named entity 'Kaplan-Meier plot' named entity 'therapeutic drugs' named entity 'arbidol' named entity 'critically ill' named entity 'pneumonia' named entity 'respiratory failure' named entity 't-tests' named entity 'arterial partial pressure of oxygen' named entity 'ACE2' named entity 'FiO2' named entity 'liver function' named entity 'Alanine aminotransferase' named entity 'critically ill' named entity 'glucocorticoids' named entity 'risk factors' named entity 'critically ill patients' named entity 'clinical outcomes' named entity 'coronavirus' named entity 'case report form' named entity 'risk factors' named entity 'COVID' named entity 'liver injury' named entity 'metabolism' named entity 'liver injury' named entity 'liver injury' named entity 'organ'

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