About: Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys
Creator	Jahrling, Peter Sullivan, Nancy Burton, Dennis Geisbert, Joan Geisbert, Thomas Parren, Paul Davis, Kelly Oswald, Wendelien
source	PMC
abstract	Prophylaxis with high doses of neutralizing antibody typically offers protection against challenge with viruses producing acute infections. In this study, we have investigated the ability of the neutralizing human monoclonal antibody, KZ52, to protect against Ebola virus in rhesus macaques. This antibody was previously shown to fully protect guinea pigs from infection. Four rhesus macaques were given 50 mg/kg of neutralizing human monoclonal antibody KZ52 intravenously 1 d before challenge with 1,000 plaque-forming units of Ebola virus, followed by a second dose of 50 mg/kg antibody 4 d after challenge. A control animal was exposed to virus in the absence of antibody treatment. Passive transfer of the neutralizing human monoclonal antibody not only failed to protect macaques against challenge with Ebola virus but also had a minimal effect on the explosive viral replication following infection. We show that the inability of antibody to impact infection was not due to neutralization escape. It appears that Ebola virus has a mechanism of infection propagation in vivo in macaques that is uniquely insensitive even to high concentrations of neutralizing antibody.
has issue date	2007-01-19(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.0030009
bibo:pmid	17238286
has license	cc0
sha1sum (hex)	b6353f8b0fcd86c2fd1e6f27c9b18a3ccc07980b
schema:url	https://doi.org/10.1371/journal.ppat.0030009
resource representing a document's title	Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys
has PubMed Central identifier	PMC1779296
has PubMed identifier	17238286
schema:publication	PLoS Pathog
resource representing a document's body	covid:b6353f8b0fcd86c2fd1e6f27c9b18a3ccc07980b#body_text
is schema:about of	named entity 'Ebola virus' named entity 'acute' named entity 'infection' named entity 'antibody' named entity 'NEUTRALIZATION' named entity 'EBOLA VIRUS INFECTION' named entity 'PRODUCING' named entity 'ANTIBODY' named entity 'MECHANISM' named entity 'EBOLA VIRUS' named entity 'VIRUSES' named entity 'ESCAPE' named entity 'TRANSFER' named entity 'CONCENTRATIONS' named entity 'PASSIVE' named entity 'PROTECTION' named entity 'EFFECT' named entity 'FOLLOWED BY' named entity 'CHALLENGE' named entity 'MINIMAL' named entity 'EXPLOSIVE' named entity 'CONTROL ANIMAL' named entity 'VIRAL REPLICATION' named entity 'PREVIOUSLY' named entity 'DUE TO' named entity 'FULLY' named entity 'FOLLOWING' named entity 'BUT' named entity 'ACUTE INFECTIONS' named entity 'INABILITY' named entity 'GIVEN' named entity 'MG%' named entity 'PROPAGATION' named entity 'ABSENCE OF' named entity 'IN VIVO' named entity 'IMPACT' named entity 'ANTIBODY TREATMENT' named entity 'VIRUS' named entity 'PROPHYLAXIS' named entity 'MACAQUES' named entity 'PLAQUE-FORMING UNITS' named entity 'STUDY' named entity 'DOSES' named entity 'COURSE' named entity 'FAILS' named entity 'NEUTRALIZING ANTIBODY' named entity 'FAILED' named entity 'INFECTION' named entity 'EXPOSED TO' named entity 'INSENSITIVE' named entity 'GUINEA PIGS' named entity 'HUMAN' named entity 'MONOCLONAL ANTIBODY' named entity 'RHESUS MACAQUES' named entity 'SECOND' named entity 'INTRAVENOUSLY' named entity 'MONKEYS' named entity 'HAVE' named entity 'HIGH' named entity 'IMPACT' named entity 'DOSE' named entity 'ABILITY' named entity 'INVESTIGATED' named entity 'NEUTRALIZING ANTIBODY' covid:arg/b6353f8b0fcd86c2fd1e6f27c9b18a3ccc07980b named entity 'Ebola virus' named entity 'macaques' named entity 'mechanism' named entity 'Ebola virus' named entity 'Passive transfer' named entity 'macaques' named entity 'Ebola' named entity 'macaques' named entity 'antibody'

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