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About:
Immune response characterization of mice immunized with Lactobacillus plantarum expressing spike antigen of transmissible gastroenteritis virus
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Immune response characterization of mice immunized with Lactobacillus plantarum expressing spike antigen of transmissible gastroenteritis virus
Creator
Liu, Jing
Wang, Guan
Huang, Hai-Bin
Jiang, Yan-Long
Kang, Yuan-Huan
Shi, Chun-Wei
Wang, Chun-Feng
Wang, Jian-Zhong
Yang, Gui-Lian
Yang, Wen-Tao
Beshir, Emad
Li, Qiong-Yan
Source
Medline; PMC
abstract
The highly infectious porcine transmissible gastroenteritis virus (TGEV), which belongs to the coronaviruses (CoVs), causes diarrhea and high mortality rates in piglets, resulting in severe economic losses in the pork industry worldwide. In this study, we used Lactobacillus plantarum (L. plantarum) to anchor the expression of TGEV antigen (S) to dendritic cells (DCs) via dendritic cell-targeting peptides (DCpep). The results show that S antigen could be detected on the surface of L. plantarum by different detection methods. Furthermore, flow cytometry and ELISA techniques were used to measure the cellular, mucosal, and humoral immune responses of the different orally gavaged mouse groups. The obtained results demonstrated the significant effect of the constructed L. plantarum expressing S-DCpep fusion proteins in inducing high expression levels of B7 molecules on DCs, as well as high levels of IgG, secretory IgA, and IFN-γ and IL-4 cytokines compared with the other groups. Accordingly, surface expression of DC-targeted antigens successfully induced cellular, mucosal, and humoral immunity in mice and could be used as a vaccine.
has issue date
2018-07-28
(
xsd:dateTime
)
bibo:doi
10.1007/s00253-018-9238-4
bibo:pmid
30056514
has license
no-cc
sha1sum (hex)
b6368824d6c82934bd19d6d1ebe4a8411eb874d1
schema:url
https://doi.org/10.1007/s00253-018-9238-4
resource representing a document's title
Immune response characterization of mice immunized with Lactobacillus plantarum expressing spike antigen of transmissible gastroenteritis virus
has PubMed Central identifier
PMC7080198
has PubMed identifier
30056514
schema:publication
Appl Microbiol Biotechnol
resource representing a document's body
covid:b6368824d6c82934bd19d6d1ebe4a8411eb874d1#body_text
is
schema:about
of
named entity 'expressing'
named entity 'porcine'
named entity 'mucosal'
named entity 'inducing'
named entity 'expression'
named entity 'immunized'
named entity 'INDUSTRY'
named entity 'INFECTIOUS'
named entity 'IL-4'
named entity 'CYTOKINES'
named entity 'RESULTING IN'
named entity '28S'
named entity 'PROTEINS'
named entity 'DENDRITIC CELL'
named entity 'HIGH EXPRESSION'
named entity 'COMPARED'
named entity 'VACCINE'
named entity 'EFFECT'
named entity 'LEVELS'
named entity 'TARGETING'
named entity 'SIGNIFICANT'
named entity 'HUMORAL IMMUNITY'
named entity 'ANTIGENS'
named entity 'FLOW CYTOMETRY'
named entity 'IMMUNE RESPONSES'
named entity 'CORONAVIRUSES'
named entity 'DETECTED'
named entity 'ELISA TECHNIQUES'
named entity 'TO MEASURE'
named entity 'CONSTRUCTED'
named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS'
named entity 'EXPRESSION'
named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS'
named entity 'SURFACE'
named entity 'COULD BE'
named entity 'GROUPS'
named entity 'USED'
named entity 'FUSION'
named entity 'CELLULAR'
named entity 'OBTAINED'
named entity 'RESULTS'
named entity 'CAUSES'
named entity 'S ANTIGEN'
named entity 'SECRETORY IGA'
named entity 'ANTIGEN'
named entity 'DIARRHEA'
named entity 'MUCOSAL'
named entity 'DIFFERENT'
named entity 'ECONOMIC'
named entity 'DCS'
named entity 'HIGHLY'
named entity 'WORLDWIDE'
named entity 'MOLECULES'
named entity 'PEPTIDES'
named entity 'CHARACTERIZATION'
named entity 'LACTOBACILLUS PLANTARUM'
named entity 'ANTIGEN'
named entity 'SPIKE'
named entity 'MICE'
named entity 'IMMUNE RESPONSE'
named entity 'IMMUNIZED'
named entity 'DENDRITIC CELLS'
named entity 'DEMONSTRATED'
named entity 'MICE'
named entity 'PORK'
named entity 'IGG'
named entity 'HIGH'
named entity 'INDUCED'
named entity 'STUDY'
named entity 'MORTALITY RATES'
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