About: Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study

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About: Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
Creator	Krampera, Mauro Luppi, Mario Pagano, Livio Grossi, Paolo Grossi, P Angelucci, Emanuele Bruna, Riccardo Corradini, Paolo Corrao, Giovanni Fracchiolla, Nicola Gentile, Massimo Lanza, Francesco Marchetti, Monia Martelli, Maurizio Passamonti, Francesco Pinto, Antonio Salvini, Marco San, Policlinico Visani, Giuseppe Busca, Alessandro Cuneo, Antonio Merli, Francesco Arcaini, Italy Arcaini, Luca Armiento, Daniele Barbera, La Bertù, L Bertù, Lorenza Billio, Atto Bocchia, Monica Cairoli, Roberto Candoni, Anna Cattaneo, Chiara Cavo, Michele Ciambelli, Fabrizio Conconi, Annarita Corso, Alessandro Cuccaro, Annarosa Cudillo, Laura Derenzini, Enrico Ferrara, Felicetto Galimberti, Sara Falini, Brunangelo Fava, Carmen Federici, Augusto Ferrandina, Celestino Franchi, Matteo Galieni, Piero Gherlinzoni, Filippo Giovanni, Matteo Giuliani, Nicola Guarini, Attilio Gurrieri, Carmela Haematology, ) Ladetto, Marco Lemoli, Roberto Marchesi, Francesco Massaia, Massimo Molteni, Alfredo Morotti, Alessandro Musto, Pellegrino Oberti, Margherita Olivieri, Attilio Ortu, Elettra Pane, Fabrizio Passamonti, Passerini, Carlo Porta, Della Renzo, Nicola Rigacci, Luigi Romano, Alessandra Russo, Domenico Salvini, M Scattolin, Anna Selleri, Carmine Tafuri, Agostino Tisi, Maria Tosi, Patrizia Turrini, Mauro Vallisa, Daniele Venditti, Adriano Visco, Carlo Zappasodi, Patrizia
Source	Elsevier; Medline; PMC
abstract	Summary Background Several small studies on patients with COVID-19 and haematological malignancies are available showing a high mortality in this population. The Italian Hematology Alliance on COVID-19 aimed to collect data from adult patients with haematological malignancies who required hospitalisation for COVID-19. Methods This multicentre, retrospective, cohort study included adult patients (aged ≥18 years) with diagnosis of a WHO-defined haematological malignancy admitted to 66 Italian hospitals between Feb 25 and May 18, 2020, with laboratory-confirmed and symptomatic COVID-19. Data cutoff for this analysis was June 22, 2020. The primary outcome was mortality and evaluation of potential predictive parameters of mortality. We calculated standardised mortality ratios between observed death in the study cohort and expected death by applying stratum-specific mortality rates of the Italian population with COVID-19 and an Italian cohort of 31 993 patients with haematological malignancies without COVID-19 (data up to March 1, 2019). Multivariable Cox proportional hazards model was used to identify factors associated with overall survival. This study is registered with ClinicalTrials.gov, NCT04352556, and the prospective part of the study is ongoing. Findings We enrolled 536 patients with a median follow-up of 20 days (IQR 10–34) at data cutoff, 85 (16%) of whom were managed as outpatients. 440 (98%) of 451 hospitalised patients completed their hospital course (were either discharged alive or died). 198 (37%) of 536 patients died. When compared with the general Italian population with COVID-19, the standardised mortality ratio was 2·04 (95% CI 1·77–2·34) in our whole study cohort and 3·72 (2·86–4·64) in individuals younger than 70 years. When compared with the non-COVID-19 cohort with haematological malignancies, the standardised mortality ratio was 41·3 (38·1–44·9). Older age (hazard ratio 1·03, 95% CI 1·01–1·05); progressive disease status (2·10, 1·41–3·12); diagnosis of acute myeloid leukaemia (3·49, 1·56–7·81), indolent non-Hodgin lymphoma (2·19, 1·07–4·48), aggressive non-Hodgkin lymphoma (2·56, 1·34–4·89), or plasma cell neoplasms (2·48, 1·31–4·69), and severe or critical COVID-19 (4·08, 2·73–6·09) were associated with worse overall survival. Interpretation This study adds to the evidence that patients with haematological malignancies have worse outcomes than both the general population with COVID-19 and patients with haematological malignancies without COVID-19. The high mortality among patients with haematological malignancies hospitalised with COVID-19 highlights the need for aggressive infection prevention strategies, at least until effective vaccination or treatment strategies are available. Funding Associazione italiana contro le leucemie, linfomi e mieloma–Varese Onlus.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1016/s2352-3026(20)30251-9
bibo:pmid	32798473
has license	els-covid
sha1sum (hex)	b6604109294a6828f3ea592d8071652e4cd4fd45
schema:url	https://doi.org/10.1016/s2352-3026%2820%2930251-9
resource representing a document's title	Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
has PubMed Central identifier	PMC7426107
has PubMed identifier	32798473
schema:publication	The Lancet Haematology

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