About: Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model

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About: Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model
Creator	Yu, Yang Yang, Tao Aikemu, Ainiwaer Miao, Weiwei Omarniyaz, Zuhragul Reyimu, Renaguli Upur, Halmurat Lianlian, Shan
Source	Medline; PMC
abstract	BACKGROUND: Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. it was showed that total flavonoids of ASMq could inhibit the proliferation and enhance the antioxidant ability of human cervix cancer HeLa cell. This study attempts to confirm these effects on the transplanted cervical cancer (U27) mouse model in vivo. METHODS: Forty eight Kunming mice were randomly divided in to six groups: normal control group (Control group), U27 tumor model group (Model group), cyclophosphamide administration group (CTX group),low-dose ASMq group (ASMq.L group), medium-dose ASMq group (ASMq.M group), and high-dose ASMq group (ASMq.H group). The five groups except normal control group transplanted with cervical cancer (U27) cells. We observed mice tumor inhibition rate and conducted the histopathological analysisUsing the western blot assay, the expression of TGF-β1 and TNF-α protein in transplanted cervical cancer U27 tumor tissue were detected. RESULTS: The tumor inhibition rates of CTX group, ASMq.L group, ASMq.M group, and ASMq.H group were 72.21, 31.27, 60.53 and 51.94% respectively, has obvious antitumor effect. ASMq significantly promote the spleen tlymphocyte proliferation of transplanted cervical cancer U27 mice. Invasive growth and diffusion rate in tumor tissue were accelerate in the transplanted cervical cancer U27 model group. Tumor tissue necrosis of tumor cells are smaller in the medium, high dosage group. Compared with the U27 model group, the expression levels of TGF-β1 protein and TNF-α protein expression exhibited statistically significant decreased in the mice tumor tissues in the CTX administration group and the ASMq administration group. CONCLUSIONS: ASMq has some antitumor effects on U27 model mice in vivo, The effects are achieved not only by improving the immune function of U27 model mice, but also by inhibiting the expression levels of TGF-β1 protein while promoting the expression levels of TNF-α protein.
has issue date	2016-11-24(xsd:dateTime)
bibo:doi	10.1186/s12906-016-1458-5
bibo:pmid	27881109
has license	cc-by
sha1sum (hex)	b6d7e94615aea8a7a591d68cea8c6710ce86df13
schema:url	https://doi.org/10.1186/s12906-016-1458-5
resource representing a document's title	Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model
has PubMed Central identifier	PMC5122163
has PubMed identifier	27881109
schema:publication	BMC Complement Altern Med
resource representing a document's body	covid:b6d7e94615aea8a7a591d68cea8c6710ce86df13#body_text
is schema:about of	named entity 'flavonoids' named entity 'vivo' named entity 'transplanted' covid:arg/b6d7e94615aea8a7a591d68cea8c6710ce86df13 named entity 'enhance' named entity 'HeLa cell' named entity 'cervical cancer' named entity 'study' named entity 'mouse model' named entity 'mice' named entity 'thymus' named entity 'therapeutic effects' named entity 'TGF-β1' named entity 'anti-tumor' named entity 'tumor cell' named entity 'Kunming' named entity 'interstitial fluid' named entity 'Kunming' named entity 'homogeneity of variance' named entity 'TNF-α' named entity 'splenic' named entity 'mice' named entity 'TGF-β' named entity 'expression levels' named entity 'Thymus' named entity 'mice' named entity 'formalin' named entity 'intraperitoneal' named entity 'histopathology' named entity 'cytoplasm' named entity 'mice' named entity 'hydroxyl' named entity 'natural compound' named entity 'TGF-β1' named entity 'TNF-a' named entity 'expression levels' named entity 'necrosis' named entity 'TGF-β1' named entity 'tumor' named entity 'Alhagi pseudalhagi' named entity 'staining' named entity 'apoptosis' named entity 'control group' named entity 'liver cancer' named entity 'anti-tumor' named entity 'cervical cancer' named entity 'flavonoids' named entity 'thymus' named entity 'protein expression' named entity 'tumor' named entity 'tumors' named entity 'anti-tumor' named entity 'mice' named entity '12,000' named entity 'thymus' named entity 'NK cells' named entity 'Western blot' named entity 'mice' named entity 'body fluids' named entity 'humoral immune' named entity 'tumor' named entity 'thymic' named entity 'tumor' named entity 'edema' named entity 'filter paper' named entity 'tumor' named entity 'mouse model' named entity 'anti-tumor' named entity 'protein expression' named entity 'tumor' named entity 'TGF-β1' named entity 'kidney' named entity 'spleen' named entity 'protein'

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