About: A VLP vaccine for epidemic Chikungunya virus protects non-human primates against infection

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About: A VLP vaccine for epidemic Chikungunya virus protects non-human primates against infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A VLP vaccine for epidemic Chikungunya virus protects non-human primates against infection
Creator	Med, Nat Author Contributions W.A, Z N ; W, G Performed The Research; W, S Y ; W, Z
Source	Medline; PMC
abstract	Chikungunya virus (CHIKV) has infected millions of people in Africa, Europe, and Asia1,2 since its re-emergence in Kenya in 2004. The severity of disease and spread of this epidemic virus present a serious public health threat in the absence of vaccines or anti-viral therapies. Here, we describe a novel vaccine that protects against emerging CHIKV infection of non-human primates (NHP). We show that selective expression of viral structural proteins gives rise to virus-like particles (VLPs) in vitro that resemble replication-competent alphaviruses. Immunization with these VLPs elicited neutralizing antibodies against envelope proteins from different CHIKV strains. Monkeys immunized with VLPs produced high titer neutralizing antibodies that protected against viremia after high dose challenge. We transferred these antibodies into immunodeficient mice, where they protected against subsequent lethal CHIKV challenge, establishing a humoral mechanism of protection. Immunization with alphavirus VLP vaccines represents a strategy to contain the spread of CHIKV and related pathogenic viruses in humans.
has issue date	2010-01-28(xsd:dateTime)
bibo:doi	10.1038/nm.2105
bibo:pmid	20111039
has license	no-cc
sha1sum (hex)	b6ed892b894ed62251a8cb78b5bca37318a03a4d
schema:url	https://doi.org/10.1038/nm.2105
resource representing a document's title	A VLP vaccine for epidemic Chikungunya virus protects non-human primates against infection
has PubMed Central identifier	PMC2834826
has PubMed identifier	20111039
schema:publication	Nat Med
resource representing a document's body	covid:b6ed892b894ed62251a8cb78b5bca37318a03a4d#body_text
is schema:about of	named entity 'CHIKV' named entity 'Africa' named entity 'vaccines' named entity 'immunodeficient' named entity 'transferred' named entity 'antibodies' named entity 'SELECTIVE' named entity 'VIRUSES' named entity 'INFECTED' named entity 'ITS' named entity 'PRIMATES' named entity 'TRANSFERRED' named entity 'SPREAD' named entity 'HIGH' named entity 'TITER' named entity 'REPLICATION' named entity 'DESCRIBE' named entity 'PROTECTION' named entity 'PEOPLE' named entity 'VACCINES' named entity 'STRAINS' named entity 'SEVERITY' named entity 'RISE' named entity 'HUMANS' covid:arg/b6ed892b894ed62251a8cb78b5bca37318a03a4d named entity 'IN VITRO' named entity 'IMMUNODEFICIENT' named entity 'PATHOGENIC' named entity 'CHALLENGE' named entity 'RESEARCH STUDIES' named entity 'EMERGENCE' named entity 'PROTEINS' named entity 'MECHANISM' named entity 'THERAPIES' named entity 'STRATEGY' named entity 'TO CONTAIN' named entity 'ALPHAVIRUS' named entity 'DIFFERENT' named entity 'HERE' named entity 'SUBSEQUENT' named entity 'VIRAL STRUCTURAL PROTEINS' named entity 'LETHAL' named entity 'NEUTRALIZING ANTIBODIES' named entity 'IMMUNIZED' named entity 'NOVEL' named entity 'VLP' named entity 'EUROPE' named entity 'NON-' named entity 'DISEASE' named entity 'AFRICA' named entity 'VLPS' named entity 'THESE' named entity 'IMMUNIZATION' named entity 'VIRAL' named entity 'CHIKV INFECTION' named entity 'EPIDEMIC' named entity 'MONKEYS' named entity 'ANTIBODIES' named entity 'RELATED' named entity 'EXPRESSION' named entity 'HIGH DOSE' named entity 'ABSENCE OF' named entity 'VIRUS-LIKE PARTICLES' named entity 'HUMAN' named entity 'ELICITED' named entity 'VACCINE' named entity 'COMPETENT' named entity 'ALPHAVIRUSES' named entity 'CHIKUNGUNYA VIRUS' named entity 'ESTABLISHING' named entity 'WHERE' named entity 'ENVELOPE' named entity 'MICE' named entity 'VIRUS PRESENT' named entity 'VIREMIA' named entity 'KENYA' named entity 'public health'

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