About: TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury

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About: TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury
Creator	Jiang, Xi Tong, Yao Li, Quan Billiar, Timothy Zhang, Liming Chen, Zhixia Ding, Xibing Jin, Shuqing Mei, Shuya
Source	PMC
abstract	Acute lung injury is a life-threatening inflammatory response caused by severe infection. Toll-like receptors in alveolar macrophages (AMΦ) recognize the molecular constituents of pathogens and activate the host’s innate immune responses. Numerous studies have documented the importance of TLR-TLR cross talk, but few studies have specifically addressed the relationship between TLR4 and TLR3. We explored a novel mechanism of TLR3 up-regulation that is induced by LPS-TLR4 signaling in a dose- and time-dependent manner in AMΦ from C57BL/6 mice, while the LPS-induced TLR3 expression was significantly reduced in TLR4(−/−) and Myd88(−/−) mice and following pretreatment with a NF-κB inhibitor. The enhanced TLR3 up-regulation in AMΦ augmented the expression of cytokines and chemokines in response to sequential challenges with LPS and Poly I:C, a TLR3 ligand, which was physiologically associated with amplified AMΦ-induced PMN migration into lung alveoli. Our study demonstrates that the synergistic effect between TLR4 and TLR3 in macrophages is an important determinant in acute lung injury and, more importantly, that TLR3 up-regulation is dependent on TLR4-MyD88-NF-κB signaling. These results raise the possibility that bacterial infections can induce sensitivity to viral infections, which may have important implications for the therapeutic manipulation of the innate immune system.
has issue date	2017-02-15(xsd:dateTime)
bibo:doi	10.1038/srep34278
bibo:pmid	28198368
has license	cc-by
sha1sum (hex)	b6f1886154af3ff272e59a9a82b310373330a9ce
schema:url	https://doi.org/10.1038/srep34278
resource representing a document's title	TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury
has PubMed Central identifier	PMC5309825
has PubMed identifier	28198368
schema:publication	Sci Rep
resource representing a document's body	covid:b6f1886154af3ff272e59a9a82b310373330a9ce#body_text
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