About: Development of ultrahigh‐performance liquid chromatography‐ mass spectrometry and ultrahigh‐performance supercritical fluid chromatography‐mass spectrometry assays to determine the concentration of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Development of ultrahigh‐performance liquid chromatography‐ mass spectrometry and ultrahigh‐performance supercritical fluid chromatography‐mass spectrometry assays to determine the concentration of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of ultrahigh‐performance liquid chromatography‐ mass spectrometry and ultrahigh‐performance supercritical fluid chromatography‐mass spectrometry assays to determine the concentration of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions
Creator	Herniman, Julie Langley, John
Source	Medline; PMC
abstract	RATIONALE: Fast and easily transferable chromatography‐mass spectrometry assays were required to detect and quantify the amount of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions. METHODS: Bitrex™ solutions were analysed using reversed phase ultrahigh‐performance liquid chromatography coupled with positive ion electrospray ionisation mass spectrometry (UHPLC/MS). Separation was achieved using a mobile phase gradient with an Acquity BEH C18 packed column. Sodium saccharin solutions were analysed using ultrahigh‐performance supercritical fluid chromatography coupled with negative ion electrospray ionisation (UHPSFC/MS). Separation was achieved using isocratic elution with an Acquity UPC(2) Torus Diol packed column and a methanol (25 mM ammonium acetate) co‐solvent. RESULTS: The calibration curves obtained using the ratio of the active compound an internal standard generated linear regression values (R(2)) > 0.99. Samples analysed prior to and after an autoclave sterilisation process and bottling give repeatable measurements within 10% of the expected concentration. CONCLUSIONS: The two assays afford a fast robust and quantitative analytical method for the detection of the active components used to test the efficacy of the homemade facemask testing solutions.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.1002/rcm.8848
bibo:pmid	32492215
has license	no-cc
sha1sum (hex)	b6fe7ae78bfa4da86f7688d0606f4307f930ac98
schema:url	https://doi.org/10.1002/rcm.8848
resource representing a document's title	Development of ultrahigh‐performance liquid chromatography‐ mass spectrometry and ultrahigh‐performance supercritical fluid chromatography‐mass spectrometry assays to determine the concentration of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions
has PubMed Central identifier	PMC7300544
has PubMed identifier	32492215
schema:publication	Rapid Commun Mass Spectrom
resource representing a document's body	covid:b6fe7ae78bfa4da86f7688d0606f4307f930ac98#body_text
is schema:about of	named entity 'fit' named entity 'TESTING' named entity 'LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ' named entity 'sodium saccharin' named entity 'fit testing' named entity 'mass spectrometry' named entity 'FFP2' named entity 'reversed phase' named entity 'personal protective equipment' named entity 'ammonium acetate' named entity 'internal standard' named entity 'respirator' named entity 'solvent' named entity 'mass spectra' named entity 'methanol' named entity 'calibration curve' named entity 'COVID-19 in the UK' named entity 'Chemistry' named entity 'electrospray ionisation' named entity 'serially diluted' named entity 'Oxybutynin chloride' named entity 'sodium saccharin' named entity 'Gillingham, UK' named entity 'toxic chemicals' named entity 'particle size' named entity 'ammonium acetate' named entity 'sodium saccharin' named entity 'methanol' named entity 'particle size' named entity 'formic acid' named entity 'vanillic acid' named entity 'formic acid' named entity 'vanillic acid' named entity 'respirator' named entity 'calibration curve' named entity 'sodium saccharin' named entity 'oxybutynin chloride' named entity 'autoclave' named entity 'denatonium benzoate' named entity 'internal standard' named entity 'oxybutynin chloride' named entity 'internal standard' named entity 'liquid chromatograph' named entity 'Loughborough' named entity 'isocratic' named entity 'chromatography' named entity 'University of Southampton' named entity 'internal standard' named entity 'negative ion' named entity 'negative ion' named entity 'methanol' named entity 'methanol' named entity 'autoclave' named entity 'ammonium acetate' named entity 'Fit Test' named entity 'reversed phase' named entity 'sodium saccharin' named entity 'sodium saccharin' named entity 'normal phase chromatography' named entity '2.0' named entity 'analytical quality control' named entity 'mobile phase' named entity 'solvent' named entity 'solvent' named entity 'autoclave' named entity 'sodium saccharin' named entity 'Positive ion' named entity 'sterilisation' named entity 'methanol' named entity 'Nichols plc' named entity 'calibration' named entity 'internal standard' named entity 'diluent' named entity 'vanillic acid' named entity 'deprotonated' named entity 'solvent' named entity 'respirator' named entity '10.4' named entity 'ng/mL' named entity 'oxybutynin chloride'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software