About: In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate

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About: In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate
Creator	Li, Juan Zhang, Hong Wang, Juan Jiang, Yanfang Niu, Junqi Xu, Kun Li, Jinhua Li, Yangguang Wang, Enbo Yuan, Ye Zhang, Shiyao Qi, Yan-Fei
Source	Elsevier; Medline; PMC
abstract	Abstract A structural determined heteropolytungstate, [K4(H2O)8Cl][K4(H2O)4PTi2W10O40]·NH2OH 1, has been synthesized and evaluated for in vitro antiviral activities against hepatitis B (HBV) and SARS virus. The identity and high purity of compound 1 were confirmed by elemental analysis, NMR, IR analysis and single-crystal X-ray diffraction. The compound 1, evaluated in HepG 2.2.15 cells expressing permanently HBV, significantly reduced the levels of HBV antigens and HBV DNA in a dose-dependent and time-dependent manner. EC50 values were determined to be 54μM for HBeAg, 61μM for HBsAg and 2.66μM for supernatant HBV DNA, as compared to 1671, 1570, 169μM, respectively, for the commercially-available hepatitis B drug adefovir dipivoxil (ADV). Intracellular cccDNA, pgRNA and HBcAg were also found to be decreased by compound 1 in a concentration-dependent manner. Cytotoxicity results showed that compound 1 has low toxicity in HepG 2 cells with CC50 value of 515.20μM. The results indicate that compound 1 can efficiently inhibit HBV replication in HepG 2.2.15 cells line in vitro. Additionally, compound 1 also shows high anti-SARS activity at an EC50 of 7.08μM and toxicity with a CC50 of 118.6μM against MDCK cells.
has issue date	2012-01-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2011.11.003
bibo:pmid	22127069
has license	els-covid
sha1sum (hex)	b70a7f9ce81a1b8721bc17273cd01674e574f56e
schema:url	https://doi.org/10.1016/j.antiviral.2011.11.003
resource representing a document's title	In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate
has PubMed Central identifier	PMC7114352
has PubMed identifier	22127069
schema:publication	Antiviral Research
resource representing a document's body	covid:b70a7f9ce81a1b8721bc17273cd01674e574f56e#body_text
is schema:about of	named entity 'compared' named entity 'DNA' named entity 'SARS VIRUS' named entity 'LOW TOXICITY' named entity 'ACTIVITIES' named entity 'HBEAG' named entity 'DEPENDENT' named entity 'DOSE-DEPENDENT' named entity 'ANTIVIRAL' named entity 'COMPOUND' named entity 'ACTIVITY' named entity 'CONFIRMED BY' named entity 'SUPERNATANT' named entity 'CONCENTRATION' covid:arg/b70a7f9ce81a1b8721bc17273cd01674e574f56e named entity 'ACTIVITIES' named entity 'TIME' named entity 'SINGLE-CRYSTAL X-RAY DIFFRACTION' named entity 'FOUND' named entity 'NMR' named entity 'DECREASED BY' named entity 'ANALYSIS' named entity 'RESULTS' named entity 'VALUE' named entity 'SYNTHESIZED' named entity 'HIGH' named entity 'STRUCTURAL' named entity 'AVAILABLE' named entity 'HBV DNA' named entity 'ADEFOVIR DIPIVOXIL' named entity 'IN VITRO' named entity 'ELEMENTAL ANALYSIS' named entity '28H' named entity 'LEVELS' named entity 'IN VITRO' named entity 'TITANIUM' named entity 'HEPATITIS B' named entity 'VALUES' named entity 'CYTOTOXICITY' named entity '118' named entity '2.2.15' named entity '7.08' named entity 'PTI' named entity 'CELLS LINE' named entity 'COMPARED' named entity 'REPLICATION' named entity 'DETERMINED' named entity '2 O' named entity 'MDCK CELLS' named entity 'CCCDNA' named entity 'INTRACELLULAR' named entity 'HBSAG' named entity 'ANTIGENS' named entity 'SARS VIRUS' named entity 'IDENTITY' named entity 'HEPATITIS B' named entity 'EVALUATED' named entity 'REDUCED' named entity 'CELLS' named entity 'TOXICITY' named entity 'SARS' named entity 'HBV' named entity 'DRUG' named entity 'HBCAG' named entity 'PURITY' named entity 'PGRNA' named entity 'structural' named entity 'compound' named entity 'HBV' named entity 'reduced'

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