About: Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective
Creator	Bandyopadhyay, Uday Bindu, Samik Mazumder, Somnath
Source	Elsevier; Medline; PMC
abstract	Owing to the efficacy in reducing pain and inflammation non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines, confirming their position in the WHO’s Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable. Apart from analgesic, anti-inflammatory and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks. However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral and pulmonary complications. Although extensive research has elucidated the mechanisms underlying the clinical hazards of NSAIDs, no review has extensively collated the outcomes on various multiorgan toxicities of these drugs together. In this regard, the present review provides a comprehensive insight of the existing knowledge and recent developments on NSAID-induced organ damage. It precisely encompasses the current understanding of structure, classification and mode of action of NSAIDs while reiterating on the emerging instances of NSAID drug repurposing along with pharmacophore modification aimed at safer usage of NSAIDs where toxic effects are tamed without compromising the clinical benefits. The review does not intend to vilify these ‘wonder drugs’; rather provide a careful understanding of their side-effects which would be beneficial in evaluating the risk-benefit threshold while rationally using NSAIDs at safer dose and duration.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1016/j.bcp.2020.114147
bibo:pmid	32653589
has license	no-cc
sha1sum (hex)	b72eb594eb36efbd75993db2fd32832e528a38e8
schema:url	https://doi.org/10.1016/j.bcp.2020.114147
resource representing a document's title	Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective
has PubMed Central identifier	PMC7347500
has PubMed identifier	32653589
schema:publication	Biochem Pharmacol
resource representing a document's body	covid:b72eb594eb36efbd75993db2fd32832e528a38e8#body_text
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