About: Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination

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About: Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination
Creator	Calzada-Nova, Gabriela Husmann, Robert Schnitzlein, William Dawson, Harry Lunney, Joan Royaee, Atabak Zuckermann, Federico
Source	Elsevier; Medline; PMC
abstract	The natural response of pigs to porcine reproductive and respiratory syndrome virus (PRRSV) infections and vaccinations needs to be altered so that better protection is afforded against both homologous and heterologous challenges by this pathogen. To address this problem, real-time gene expression assays were coupled with cytokine Elispot and protein analyses to assess the nature of the anti-PRRSV response of pigs immunized with modified live virus (MLV) vaccine. Although T helper 1 (Th1) immunity was elicited in all vaccinated animals, as evidenced by the genesis of PRRSV-specific interferon-gamma secreting cells (IFNG SC), the overall extent of the memory response was variable and generally weak. Peripheral blood mononuclear cells (PBMC) isolated from these pigs responded to PRRSV exposure with a limited increase in their expression of the Th1 immune markers, IFNG, tumor necrosis factor-alpha and interleukin-15 (IL15), and a reduction in the quantity of mRNAs encoding the innate and inflammatory proteins, IL1B, IL8 and IFNA. Efforts to enhance Th1 immunity, by utilizing an expression plasmid encoding porcine IFNA (pINA) as an adjuvant, resulted in a temporary increase in the frequency of PRRSV-specific IFNG SC but only minor changes overall in the expression of Th1 associated cytokine or innate immune marker mRNA by virus-stimulated PBMC. Administration of pINA, however, did correlate with decreased IL1B secretion by cultured, unstimulated PBMC but had no effect on their ability to release IFNG. Thus, while exogenous addition of IFNA during PRRSV vaccination has an impact on the development of a Th1 immune response, other alterations will be required for substantial boosting of virus-specific protection.
has issue date	2004-12-08(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2004.09.018
bibo:pmid	15507306
has license	no-cc
sha1sum (hex)	b7cfc8e761e9ca94fce58b846884eec614d4350d
schema:url	https://doi.org/10.1016/j.vetimm.2004.09.018
resource representing a document's title	Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination
has PubMed Central identifier	PMC7112652
has PubMed identifier	15507306
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:b7cfc8e761e9ca94fce58b846884eec614d4350d#body_text
is schema:about of	named entity 'release' named entity 'reduction' named entity 'expression' named entity 'vaccine' named entity 'pINA' named entity 'assess' named entity 'vaccinated' named entity 'cytokine' named entity 'factors' named entity 'RESPONSE TO' named entity 'IMMUNE' named entity 'PINA' named entity 'MEMORY' named entity 'LIMITED' named entity 'ADDRESS' named entity 'BUT' named entity 'THESE' named entity 'INFECTIONS' named entity 'PORCINE' named entity 'SECRETING' named entity 'HETEROLOGOUS' named entity 'ENHANCE' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'MINOR' named entity 'GENE EXPRESSION' named entity 'NATURAL' named entity 'TUMOR NECROSIS FACTOR-ALPHA' named entity 'IMMUNITY' named entity 'PIGS' named entity 'TEMPORARY' named entity 'IFNG' named entity 'IMMUNE MARKERS' named entity 'BETTER' named entity 'CHANGES' named entity 'NATURE' named entity 'IL1B' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'EXPRESSION' named entity 'ALTERED' named entity 'PRRSV' named entity 'PROTEINS' named entity 'IMMUNE' named entity 'ADMINISTRATION' named entity 'GENERALLY' named entity 'CELLS' named entity 'PROTEIN ' named entity 'IL8' named entity 'ELISPOT' named entity 'UNSTIMULATED' named entity 'STIMULATED' named entity 'LIVE' named entity 'REAL-TIME' named entity 'ASSESS' named entity 'MRNA' named entity 'EXPOSURE' named entity 'DECREASED IL1B SECRETION' named entity 'MRNAS' named entity 'DID' named entity 'REDUCTION' named entity 'HOMOLOGOUS' named entity 'ANIMALS' named entity 'PBMC' named entity 'PROBLEM' named entity 'GENESIS' named entity 'VARIABLE' named entity 'PROTECTION' named entity 'HOST RESPONSE' named entity 'DEVELOPMENT' named entity 'INFLAMMATORY' named entity 'FREQUENCY' named entity 'VACCINE' named entity 'ELICITED' named entity 'INTERFERON-GAMMA' named entity 'T HELPER' named entity 'ISOLATED'

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