About: THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS

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About: THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS
Creator	Marcello, Alessandro Lembo, David Rajasekharan, Sreejith Civra, Andrea Leoni, Valerio Poli, Giuseppe Cavalli, Roberta Bonotto, Rafaela Adami, Marco Brambilla, Paolo Caccia, Claudio Giacobone, Chiara Nascimento, Alves Alves Nascimento, Lais
source	Elsevier; Medline; PMC
abstract	There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on. Specific side-chain cholesterol oxidation products of the oxysterols family have been shown to inhibit a large variety of both enveloped and non-enveloped human viral pathogens. Here we report on the in vitro inhibitory activity of the redox active oxysterol 27-hydroxycholesterol against SARS-CoV-2 and against one of the common cold agents HCoV-OC43 human coronavirus without significant cytotoxicity. Interestingly, physiological serum levels of 27-hydroxycholesterol in SARS-CoV-2 positive subjects were significantly decreased compared to the matched control group, reaching a marked 50% reduction in severe COVID-19 cases. Moreover, no correlation at all was observed between 24-hydroxycholesterol and 25-hydroxycholesterol serum levels and the severity of the disease. Opposite to that of 27-hydroxycholesterol was the behaviour of two recognized markers of redox imbalance, i.e. 7-ketocholesterol and 7β-hydroxycholesterol, whose serum levels were significantly increased especially in severe COVID-19. The exogenous administration of 27-hydroxycholesterol may represent in the near future a valid antiviral strategy in the worsening of diseases caused by present and emerging coronaviruses.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1016/j.redox.2020.101682
bibo:pmid	32810737
has license	no-cc
sha1sum (hex)	b7d250c35c28644fc47ce18fb21bd8534d105353
schema:url	https://doi.org/10.1016/j.redox.2020.101682
resource representing a document's title	THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS
has PubMed Central identifier	PMC7416714
has PubMed identifier	32810737
schema:publication	Redox Biol
resource representing a document's body	covid:b7d250c35c28644fc47ce18fb21bd8534d105353#body_text
is schema:about of	named entity 'oxysterol' named entity 'coronavirus' named entity 'cholesterol' named entity 'COVID-19' named entity 'active' named entity '27-hydroxycholesterol' named entity 'COVID-19' named entity 'redox' named entity 'COVID-19 pandemic' named entity 'oxidation' named entity 'coronavirus' named entity 'inhibitory activity' named entity '27-hydroxycholesterol' named entity 'CHOLESTEROL' named entity 'SARS' named entity 'COVID-19' named entity 'endosomal' named entity 'SARS-CoV-2' named entity 'GC-MS' named entity 'oxidation' named entity 'COVID-19' named entity 'receptor' named entity 'ANOVA' named entity 'SARS-CoV-2' named entity 'biogenesis' named entity 'asymptomatic' named entity 'ion' named entity 'Creatine Kinase' named entity 'biological fluids' named entity 'Vero E6' named entity 'MRC-5' named entity 'clinical laboratory' named entity 'COVID-19' named entity 'control group' named entity 'Respiratory syncytial virus' named entity 'mitochondrial' named entity 'TLR4' named entity 'Alamar Blue' named entity 'human coronavirus' named entity 'Germany' named entity 'antiviral' named entity 'carboxymethylcellulose' named entity 'antiviral activity' named entity 'lanosterol' named entity 'polymerase-chain-reaction' named entity 'MRC-5' named entity 'HSP60' named entity 'cell structures' named entity 'antiviral activity' named entity 'cholesterol metabolism' named entity 'SARS-CoV-2' named entity 'sterols' named entity 'dramatic impact' named entity 'selected-ion monitoring' named entity 'DMEM' named entity 'CO2' named entity 'mannose-6-phosphate' named entity 'viruses' named entity 'human blood' named entity 'oxidative stress' named entity 'Procalcitonin' named entity 'solubility' named entity 'viral infections' named entity 'vesicles' named entity 'sepsis' named entity 'phylogenetically' named entity 'OC43' named entity 'SARS-CoV-2'

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