About: Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies

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About: Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies
Creator	Horzinek, Marian Niesters, Hubert Bleumink-Pluym, Nancy Osterhaus, Van Der Zeijst, Bernard
Source	Elsevier; Medline; PMC
abstract	Abstract Sixteen monoclonal antibodies (Mcabs) were prepared against infectious bronchitis virus strain M41, all of them reacting with the peplomer protein. One of them, Mcab 13, was able to neutralize the virus and to inhibit hemagglutination. Competition binding assays allowed the definition of five epitopes, designated as A, B, C, D, and E, of which epitopes A and B are overlapping. Furthermore, the binding of Mcab 13 (epitope E) could be enhanced by the addition of Mcabs from group B, C, and D. A dot immunoblot assay was used to analyze the effect of denaturation on antibody recognition of the epitopes. Only the binding of Mcab 13 was affected, indicating that the epitope involved in neutralization and hemagglutination is conformation dependent. The epitopes A to D were highly conserved among IBV strains, while epitope E was specific for strains M41 and D3896. In this last strain, however, this epitope was not involved in neutralization.
has issue date	1987-12-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(87)90145-0
bibo:pmid	2446423
has license	els-covid
sha1sum (hex)	b7df37353c137e7045aa8d1027d548b2b8cbcb1b
schema:url	https://doi.org/10.1016/0042-6822%2887%2990145-0
resource representing a document's title	Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies
has PubMed Central identifier	PMC7131525
has PubMed identifier	2446423
schema:publication	Virology
resource representing a document's body	covid:b7df37353c137e7045aa8d1027d548b2b8cbcb1b#body_text
is schema:about of	named entity 'Competition' named entity 'CONFORMATION' named entity 'GROUP B' named entity 'BINDING ASSAYS' named entity 'ENHANCED' named entity 'ADDITION' named entity 'BINDING' named entity 'MCAB' named entity 'DEPENDENT' named entity 'ANTIBODY' named entity 'DESIGNATED' named entity 'STRAINS' named entity 'ALLOWED' named entity 'ONE OF' named entity 'HIGHLY' named entity 'IMMUNOBLOT ASSAY' named entity 'EFFECT' named entity 'MONOCLONAL ANTIBODIES' named entity 'M41' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'RECOGNITION' named entity 'OVERLAPPING' named entity 'STRAIN' named entity 'AFFECTED' named entity 'CONSERVED' named entity 'INVOLVED' named entity 'EPITOPES' named entity 'EPITOPES' named entity 'COULD BE' named entity 'COMPETITION BINDING' named entity 'DEFINED' named entity 'STRAIN' named entity 'USED' named entity 'NOT INVOLVED' named entity 'SPECIFIC' named entity 'EPITOPE' named entity 'MONOCLONAL ANTIBODIES' named entity 'SIXTEEN' named entity 'INDICATING' named entity 'PROTEIN ' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'M41' named entity 'DEFINITION' named entity 'HEMAGGLUTINATION' named entity 'DOT' named entity 'TO INHIBIT' named entity 'VIRUS' named entity 'PREPARED' named entity 'DENATURATION' named entity 'PROTEIN' covid:arg/b7df37353c137e7045aa8d1027d548b2b8cbcb1b named entity 'epitope' named entity 'monoclonal antibodies' named entity 'binding' named entity 'antibody' named entity 'virus' named entity 'Bronchitis' named entity 'epitopes' named entity 'epitopes' named entity 'peplomer' named entity 'antibody' named entity 'immunoblot assay' named entity 'epitope' named entity 'infectious bronchitis virus' named entity 'Infectious Bronchitis Virus' named entity 'Sixteen' named entity 'Freund's adjuvant' named entity 'IBV' named entity 'w/v' named entity 'IBV' named entity 'protein' named entity 'infection' named entity 'Antigen' named entity 'intravenously' named entity 'cell lines' named entity 'IBV' named entity 'biological function'

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