About: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials?

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials?
Creator	Molinari, Nicolas Vachier, Isabelle Bourdin, Arnaud Chanez, Pascal Gamez, Anne-Sophie Halimi, Laurence Jaffuel, Dany Marciano, Julie Pahus, Laurie Suehs, Carey
Source	Medline; PMC
abstract	BACKGROUND: Patient skepticism concerning medical innovations can have major consequences for current public health and may threaten future progress, which greatly relies on clinical research. The primary objective of this study is to determine the variables associated with patient acceptation or refusal to participate in clinical research. Specifically, we sought to evaluate if distrust in pharmaceutical companies and associated psychosocial factors could represent a recruitment bias in clinical trials and thus threaten the applicability of their results. METHODS: This prospective, multicenter survey consisted in the administration of a self-questionnaire to patients during a pulmonology consultation. The 1025 questionnaires distributed collected demographics, socio-professional and basic health literacy characteristics. Patients were asked to rank their level of trust for pharmaceutical companies and indicate their willingness to participate in different categories of research (pre or post marketing, sponsored by an academic institution or pharmaceutical company). Logistic regression was used to determine factors contributing to “trust” versus “distrust” group membership and willingness to participate in each category of research. RESULTS: One thousand patients completed the survey, corresponding to a response rate of 97.5%. Data from 838 patients were analyzed in this study. 48.3% of respondents declared that they trusted pharmaceutical companies, while 35.5% declared distrust. Being female (p = 0.042), inactive in the employment market(p = 0.007), and not-knowing the name of one’s disease(p = 0.010) are factors related to declared distrust. Distrust-group membership is associated with unwillingness to participate in certain categories of trials such as pre-marketing and industry-sponsored trials. CONCLUSION: Distrust in pharmaceutical companies is associated with a specific patient profile and with refusal to participate in certain subcategories of trials. This potential recruitment bias may explain the under-representation of certain categories of patients such as women in pre-marketing drug trials.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1186/s12910-020-00509-y
bibo:pmid	32791969
has license	cc-by
sha1sum (hex)	b7fcdb0bcf9ee623875bf89e788a39f3af6e1c35
schema:url	https://doi.org/10.1186/s12910-020-00509-y
resource representing a document's title	Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials?
has PubMed Central identifier	PMC7424561
has PubMed identifier	32791969
schema:publication	BMC Med Ethics
resource representing a document's body	covid:b7fcdb0bcf9ee623875bf89e788a39f3af6e1c35#body_text
is schema:about of	named entity 'current' named entity 'FUTURE' named entity 'DISTRUST' named entity 'CLINICAL TRIALS' covid:arg/b7fcdb0bcf9ee623875bf89e788a39f3af6e1c35 named entity 'variables' named entity 'primary objective' named entity 'clinical research' named entity 'clinical research' named entity 'psychosocial factors' named entity 'clinical trials' named entity 'clinical trials' named entity 'clinical trials' named entity 'pharmaceutical companies' named entity 'clinical trials' named entity 'clinical trials' named entity 'psychologist' named entity 'pharmaceutical companies' named entity 'psychologist' named entity 'sleep disorder' named entity 'clinical trial' named entity 'independent ethics committee' named entity 'France' named entity 'respiratory diseases' named entity 'drug trials' named entity 'explanatory variable' named entity 'ethnicity' named entity 'likert scale' named entity 'clinical trials' named entity 'health policy makers' named entity 'clinical trials' named entity 'clinical research' named entity 'psychosocial' named entity 'decision-making' named entity 'questionnaire' named entity 'clinical trials' named entity 'altruism' named entity 'pharmaceutical industry' named entity 'clinical trials' named entity 'sleep disorders' named entity 'adverse events' named entity 'health care' named entity 'pharmaceutical companies' named entity 'chronic respiratory disease' named entity 'peer-reviewed' named entity 'pharmaceutical industry' named entity 'pharmaceutical company' named entity 'statistical analyses' named entity 'missing data' named entity 'questionnaire' named entity 'pharmaceutical industry' named entity 'questionnaire' named entity 'clinical trials' named entity 'pharmaceutical companies' named entity 'Questionnaire' named entity 'external validity' named entity 'pathology' named entity 'Boujan-sur-Libron' named entity 'communication media' named entity 'drug trials' named entity 'clinical research' named entity 'decision-making' named entity 'pharmaceutical products' named entity 'clinical trials' named entity 'pharmaceutical companies' named entity 'questionnaire' named entity 'risk factors' named entity 'healthcare systems' named entity 'vaccine' named entity 'pharmaceutical companies' named entity 'healthcare systems' named entity 'clinical trials'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software