About: Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein

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About: Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein
Creator	Nishitsuji, Hironori Hayashi, Takaya Kannagi, Mari Ae, Ahmed Ae, Hasegawa Ae, Masuda Ae, Nakahama Ae, Nishigaki Atsuhiko, A Kazuo, A Morita, Ikuo Nursarat, A Obitsu, Saemi Takao, A
source	Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a lung disease with high mortality. In addition, osteonecrosis and bone abnormalities with reduced bone density have been observed in patients following recovery from SARS, which were partly but not entirely explained by the short-term use of steroids. Here, we demonstrate that human monocytes, potential precursors of osteoclasts, partly express angiotensin converting enzyme 2 (ACE2), a cellular receptor of SARS-CoV, and that expression of an accessory protein of SARS-CoV, 3a/X1, in murine macrophage cell line RAW264.7 cells, enhanced NF-κB activity and differentiation into osteoclast-like cells in the presence of receptor activator of NF-κB ligand (RANKL). Furthermore, human epithelial A549 cells expressed ACE2, and expression of 3a/X1 in these cells up-regulated TNF-α, which is known to accelerate osteoclastogenesis. 3a/X1 also enhanced RANKL expression in mouse stromal ST2 cells. These findings indicate that SARS-CoV 3a/X1 might promote osteoclastogenesis by direct and indirect mechanisms.
has issue date	2009-08-14(xsd:dateTime)
bibo:doi	10.1007/s00705-009-0472-z
bibo:pmid	19685004
has license	no-cc
sha1sum (hex)	b879b00ba0310b2582499d337ceeba46632a21ba
schema:url	https://doi.org/10.1007/s00705-009-0472-z
resource representing a document's title	Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein
has PubMed Central identifier	PMC7086770
has PubMed identifier	19685004
schema:publication	Arch Virol
resource representing a document's body	covid:b879b00ba0310b2582499d337ceeba46632a21ba#body_text
is schema:about of	named entity 'demonstrate' named entity 'potential' named entity 'steroids' named entity 'epithelial' named entity 'SARS-CoV' named entity 'enzyme' named entity 'MECHANISMS' named entity 'POTENTIAL' named entity 'UP-REGULATED' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'LIKE' named entity 'OBSERVED' named entity 'DIFFERENTIATION' named entity 'ABNORMALITIES' named entity 'ACTIVATOR OF' named entity 'KNOWN' named entity 'RECEPTOR ACTIVATOR' named entity 'PRECURSORS' covid:arg/b879b00ba0310b2582499d337ceeba46632a21ba named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'STROMAL' named entity 'EXPRESSION' named entity 'CAUSES' named entity 'PRESENCE OF' named entity 'LIGAND' named entity 'SARS-COV' named entity 'USE OF STEROIDS' named entity 'RECOVERY' named entity 'CELLS' named entity 'MORTALITY' named entity 'A549 CELLS' named entity 'HIGH' named entity 'EXPLAINED' named entity 'DIRECT' named entity 'PATIENTS' named entity 'BONE' named entity 'RAW264.7' named entity 'OSTEOCLASTS' named entity 'REDUCED BONE DENSITY' named entity 'ST2' named entity 'FINDINGS' named entity 'MACROPHAGE CELL LINE' named entity 'ACTIVITY' named entity 'PROTEIN' named entity 'POTENTIAL' named entity 'ENHANCEMENT' named entity 'ACCELERATE' named entity 'OSTEOCLAST' named entity 'RECEPTOR' named entity 'CELLULAR' named entity 'LUNG DISEASE' named entity 'HUMAN' named entity 'FOLLOWING' named entity 'EXPRESS' named entity 'SHORT-TERM' named entity 'ENHANCED' named entity 'HUMAN MONOCYTES' named entity 'INDIRECT' named entity 'ANGIOTENSIN CONVERTING ENZYME 2' named entity 'THESE' named entity 'EPITHELIAL' named entity 'SARS' named entity 'PROMOTE' named entity 'HERE' named entity 'MURINE' named entity 'ACE2' named entity 'PROTEIN ' named entity 'MOUSE'

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