About: SARS-CoV-2 Dissemination Through Peripheral Nerves Explains Multiple Organ Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 Dissemination Through Peripheral Nerves Explains Multiple Organ Injury
Creator	Maclean, Andrew Giovanni, Simone Balog, Marta Debeljak, Zeljko Fenrich, Matija Heffer, Marija Hr, Mfenrich@mefos Hr, Mheffer@mefos Mandic, Dario Mrdenovic, Stefan Roncevic, Alen Steyger, Peter Tomic, Svetlana Zjalic, Milorad
topic	covid:b8e8a3962e5e2fe46cf095abaab70d092fe761e7#this
Source	Medline; PMC
abstract	Coronavirus disease (CoVID-19), caused by recently identified severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2), is characterized by inconsistent clinical presentations. While many infected individuals remain asymptomatic or show mild respiratory symptoms, others develop severe pneumonia or even respiratory distress syndrome. SARS-CoV-2 is reported to be able to infect the lungs, the intestines, blood vessels, the bile ducts, the conjunctiva, macrophages, T lymphocytes, the heart, liver, kidneys, and brain. More than a third of cases displayed neurological involvement, and many severely ill patients developed multiple organ infection and injury. However, less than 1% of patients had a detectable level of SARS-CoV-2 in the blood, raising a question of how the virus spreads throughout the body. We propose that nerve terminals in the orofacial mucosa, eyes, and olfactory neuroepithelium act as entry points for the brain invasion, allowing SARS-CoV-2 to infect the brainstem. By exploiting the subcellular membrane compartments of infected cells, a feature common to all coronaviruses, SARS-CoV-2 is capable to disseminate from the brain to periphery via vesicular axonal transport and passive diffusion through axonal endoplasmic reticula, causing multiple organ injury independently of an underlying respiratory infection. The proposed model clarifies a wide range of clinically observed phenomena in CoVID-19 patients, such as neurological symptoms unassociated with lung pathology, protracted presence of the virus in samples obtained from recovered patients, exaggerated immune response, and multiple organ failure in severe cases with variable course and dynamics of the disease. We believe that this model can provide novel insights into CoVID-19 and its long-term sequelae, and establish a framework for further research.
has issue date	2020-08-05(xsd:dateTime)
bibo:doi	10.3389/fncel.2020.00229
bibo:pmid	32848621
has license	cc-by
sha1sum (hex)	b8e8a3962e5e2fe46cf095abaab70d092fe761e7
schema:url	https://doi.org/10.3389/fncel.2020.00229
resource representing a document's title	SARS-CoV-2 Dissemination Through Peripheral Nerves Explains Multiple Organ Injury
has PubMed Central identifier	PMC7419602
has PubMed identifier	32848621
schema:publication	Front Cell Neurosci
resource representing a document's body	covid:b8e8a3962e5e2fe46cf095abaab70d092fe761e7#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/b8e8a3962e5e2fe46cf095abaab70d092fe761e7
is schema:about of	named entity 'axonal transport' named entity 'SARS-CoV-2' named entity 'conjunctiva' named entity 'heart' named entity 'respiratory distress' named entity 'nerve' named entity 'body' named entity 'AND' named entity 'PATHOLOGY' named entity 'NEUROLOGICAL' named entity 'ITS' named entity 'BRAINSTEM' named entity 'CORONAVIRUSES' named entity 'RECENTLY' named entity 'DISPLAYED' named entity 'ENDOPLASMIC RETICULA' named entity 'invasion' named entity 'periphery' named entity 'cases' named entity 'lung' named entity 'blood vessels' named entity 'infect' named entity 'patients' named entity 'symptoms' named entity 'kidneys' named entity 'presentations' named entity 'observed' named entity 'patients' named entity 'macrophages' named entity 'endoplasmic reticula' named entity 'developed' named entity 'independently' named entity 'exploiting' named entity 'causing' named entity 'brain' named entity 'level' named entity 'disease' named entity 'cells' named entity 'Multiple' named entity 'multiple organ failure' named entity 'acute respiratory distress syndrome' named entity 'infection' named entity 'organ' named entity 'respiratory infection' named entity 'long-term' named entity 'virus' named entity 'neurological' named entity 'conjunctiva' named entity 'asymptomatic' named entity 'CoVID' named entity 'severe pneumonia' named entity 'endoplasmic reticula' named entity 'SARS-CoV-2' named entity 'intestines' named entity 'virus' named entity 'fetus' named entity 'positive-sense single-stranded RNA' named entity 'virus' named entity 'cranial ganglia' named entity 'intracellular' named entity 'neuropsychiatric' named entity 'SARS-CoV-2' named entity 'neurological' named entity 'proteases' named entity 'nasopharyngeal' named entity 'SARS-CoV-2'

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