About: The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6

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About: The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6
Creator	Jeng, King-Song Yang, Jyh-Yuan Lai, Michael Chao, Che-Yi Sung, Shu-Chiun
Source	Elsevier; Medline; PMC
abstract	Abstract The 8ab protein of SARS-CoV is a group-specific accessory protein, which is lost when the virus was transmitted from animals to humans due to a 29-nucleotide deletion in the ORF8ab region. Here we found that 8ab protein is associated with ER membrane at luminal surface. 8ab protein was found to up-regulate the synthesis of endogenous ER-resident chaperons involved in protein folding through the activation of the transcription factor ATF6, while it showed no effect on the CHOP induction and XBP1 splicing associated with the unfolded protein response (UPR). When ectopically expressed in mammalian cells, 8ab induced the proteolysis of ATF6 and the translocation of its cleaved DNA-binding and transcription-activation domains from the ER to the nucleus. Finally, we showed that 8ab binds to the luminal domain of ATF6. These findings suggest that 8ab could modulate the UPR by activating ATF6 to facilitate protein folding and processing. Thus, the loss of 8ab in SARS-CoV through viral evolution in animals may play a role in its pathogenicity.
has issue date	2009-05-10(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.02.021
bibo:pmid	19304306
has license	els-covid
sha1sum (hex)	b90348291c7b8e2b0a3ab1c467a078a732f04eff
schema:url	https://doi.org/10.1016/j.virol.2009.02.021
resource representing a document's title	The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6
has PubMed Central identifier	PMC7103415
has PubMed identifier	19304306
schema:publication	Virology
resource representing a document's body	covid:b90348291c7b8e2b0a3ab1c467a078a732f04eff#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'membrane' named entity 'transmitted' named entity 'protein folding' named entity 'DNA-binding' named entity 'ANIMALS' named entity 'PATHOGENICITY' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'TRANSCRIPTION FACTOR' named entity 'MODULATE' named entity 'TRANSLOCATION' named entity 'DUE TO' named entity 'ACTIVATION' named entity 'LOST' named entity 'LUMINAL' named entity 'ENDOGENOUS' named entity 'HUMANS' named entity 'CELLS' named entity 'PROCESSING' covid:arg/b90348291c7b8e2b0a3ab1c467a078a732f04eff named entity 'TRANSMITTED' named entity 'VIRUS' named entity 'ASSOCIATED WITH' named entity 'ACTIVATION' named entity 'ER MEMBRANE' named entity 'ATF6' named entity 'LUMINAL' named entity 'THESE' named entity 'PROTEIN FOLDING' named entity 'SPECIFIC' named entity 'VIRAL EVOLUTION' named entity 'REGULATE' named entity 'ATF6' named entity 'FOUND' named entity 'CLEAVED' named entity 'BINDING' named entity 'DOMAIN' named entity 'IS A' named entity 'MAMMALIAN' named entity 'SYNTHESIS' named entity 'FINDINGS' named entity 'PROTEIN ' named entity 'HERE' named entity 'PLAY' named entity 'ROLE' named entity 'A GROUP' named entity 'SARS-COV' named entity 'ASSOCIATED' named entity 'LOSS OF' named entity 'SURFACE' named entity 'RESIDENT' named entity 'INVOLVED' named entity 'EXPRESSED' named entity 'REGION' named entity 'DNA' named entity 'NUCLEUS' named entity 'ITS' named entity 'PROTEOLYSIS' named entity 'INDUCTION' named entity 'NUCLEOTIDE DELETION' named entity 'NO EFFECT' named entity 'ER-' named entity 'CHOP' named entity 'IS A' named entity 'ACTIVATING' named entity 'ER MEMBRANE' named entity 'SUGGEST' named entity 'INDUCED' named entity 'SARS-COV' named entity 'TRANSCRIPTION' named entity 'XBP1 SPLICING' named entity 'ACCESSORY PROTEIN' named entity 'UPR' named entity 'animals' named entity 'induced' named entity 'involved' named entity 'activating'

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