About: Individual and common inhibitors of coronavirus and picornavirus main proteases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Individual and common inhibitors of coronavirus and picornavirus main proteases
Creator	Kuo, Chih-Jung Liang, Po-Huang Liu, Hun-Ge Jung, Young-Sik Lee, Kee-In Lo, Yueh-Kuei Liang, P.-H Seong, Min
Source	Elsevier; Medline; PMC
abstract	Picornaviruses (PV) and coronaviruses (CoV) are positive-stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS-CoV 3CL(pro) with IC(50) of low μM. Interestingly, one of them equally inhibited both 3C(pro) and 3CL(pro) from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti-viral agents against PV and CoV.
has issue date	2009-02-04(xsd:dateTime)
bibo:doi	10.1016/j.febslet.2008.12.059
bibo:pmid	19166843
has license	no-cc
sha1sum (hex)	b90500a7b856b59237bc0ef1c42c132f4fd83adc
schema:url	https://doi.org/10.1016/j.febslet.2008.12.059
resource representing a document's title	Individual and common inhibitors of coronavirus and picornavirus main proteases
has PubMed Central identifier	PMC7094298
has PubMed identifier	19166843
schema:publication	FEBS Lett
resource representing a document's body	covid:b90500a7b856b59237bc0ef1c42c132f4fd83adc#body_text
is schema:about of	named entity 'wide range' named entity '6800' named entity 'MAIN' named entity 'CORONAVIRUS' named entity 'INDIVIDUAL' named entity 'COMMON' named entity 'CLINICAL OUTCOMES' named entity 'INHIBITORS' named entity 'USING' named entity 'STRUCTURAL' named entity 'ANTI-VIRAL AGENTS' named entity 'LOW' named entity 'RNA VIRUSES' named entity 'OUR' named entity 'COMPUTER MODELING' named entity 'PROTEASES' covid:arg/b90500a7b856b59237bc0ef1c42c132f4fd83adc named entity 'INHIBITORS' named entity 'KNOWLEDGE' named entity '6800' named entity 'REPORTED' named entity 'WORLDWIDE' named entity 'PROTEASE INHIBITORS' named entity 'NOVEL' named entity 'PICORNAVIRUS' named entity 'COMMON' named entity 'INDIVIDUAL' named entity 'WIDE' named entity 'RESULTING IN' named entity 'FEATURES' named entity 'ONE OF' named entity 'STUDY' named entity 'INHIBITED' named entity 'HIGH THROUGHPUT SCREENING' named entity 'IDENTIFIED' named entity 'SMALL MOLECULES' named entity 'THESE' named entity 'PICORNAVIRUSES' named entity 'ENHANCE' named entity 'POSITIVE' named entity 'PEOPLE' named entity 'INFECT' named entity 'SARS-COV' named entity 'DEVELOPING' named entity 'YEAR' named entity 'CORONAVIRUSES' named entity 'HAVE' named entity 'RANGE' named entity 'PRO' named entity 'inhibited' named entity 'structural' named entity 'protease inhibitors' named entity 'high throughput screening' named entity 'inhibitors' named entity 'small molecules' named entity 'anti-viral' named entity 'phenyl group' named entity 'H-bonds' named entity 'enteric diseases' named entity 'SARS' named entity 'proteases' named entity 'chymotrypsin-like' named entity 'proteases' named entity 'antiviral drug' named entity 'amino acid residue' named entity 'active sites' named entity 'kDa' named entity 'anti-viral drug' named entity 'nucleotides' named entity 'fluorogenic' named entity 'active site' named entity 'protease' named entity 'EV71' named entity 'SARS'

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