About: A mouse model of SARS-CoV-2 infection and pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A mouse model of SARS-CoV-2 infection and pathogenesis
Creator	Guo, Yan Chen, Qi Liu, Quan Yang, Xiao Deng, Yong-Qiang Qin, Cheng-Feng Li, Xiao-Feng Zhou, Yong Yang, Y Zhang, Na-Na Xiong, Rui Zhou, Yu-Sen Liu, Q Wang, G Zhao, X Gu, Q Deng, Y Yang, Guan Chen, S.-H Fan, Chang-Fa Fan, T.-Y Gu, Hong-Jing Guo, R Huang, Wei-Jin Huang, Xing-Yao Huang, Y.-Q Huang, Y.-X Li, N.-N Liu, Quan-Ming Liu, Su-Su Liu, W.-J Liu, X.-Y Qin, Y.-S Shen, Q.-M Shen, Yue-Lei Sun, Shi-Hui Wang, C.-F Wang, Yan-Xiao Wang, You-Chun Xiong, X.-F Yang, H.-J Zhang, S.-S Zhao, Tong-Yan Zhou, C.-F Zhou, Y.-L
source	Elsevier; Medline; PMC
abstract	Summary Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread throughout the world, resulting in a global public health emergency. The lack of vaccine and antivirals has brought an urgent need for animal model. Human Angiotensin converting enzyme II (ACE2) has been identified as a functional receptor for SARS-CoV-2. In this study, we generated a mouse model expressing human ACE2 (hACE2) using CRISPR/Cas9 knock-in technology. Compared with wild-type C57BL/6 mice, both young and aged hACE2 mice sustained high viral loads in lung, trachea and brain upon intranasal infection. Although fatalities were not observed, interstitial pneumonia and elevated cytokines were seen in SARS-CoV-2 infected- aged hACE2 mice. Interestingly, intragastric inoculation of SARS-CoV-2 was evidenced to cause productive infection and lead to pulmonary pathological changes in hACE2 mice. Overall, this animal model described here provides a useful tool for studying SARS-CoV-2 transmission and pathogenesis, and evaluating COVID-19 vaccines and therapeutics.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1016/j.chom.2020.05.020
bibo:pmid	32485164
has license	els-covid
sha1sum (hex)	b94fafe32bc30d7a93868e9d58a14485e3243c2a
schema:url	https://doi.org/10.1016/j.chom.2020.05.020
resource representing a document's title	A mouse model of SARS-CoV-2 infection and pathogenesis
has PubMed Central identifier	PMC7250783
has PubMed identifier	32485164
schema:publication	Cell Host Microbe
resource representing a document's body	covid:b94fafe32bc30d7a93868e9d58a14485e3243c2a#body_text
is schema:about of	named entity 'formatting' named entity 'enhancements' named entity 'published' named entity 'legal' named entity 'Running' named entity 'SARS-CoV-2' named entity 'DOI' named entity 'PROVIDING' named entity 'CONTENT' named entity 'AFFECT' named entity 'doi' named entity 'Cell' named entity 'pertain' named entity 'SARS-CoV-2' named entity 'infection' named entity 'infection' named entity 'SARS-CoV-2' named entity 'pathogenesis' named entity 'SARS-CoV-2' named entity 'doi' named entity 'infection' named entity 'PDF file' named entity 'infection' named entity 'typesetting' named entity 'mouse model' named entity 'record' named entity 'definitive' named entity 'PDF' named entity 'MOUSE MODEL' named entity 'SARS-CoV-2' named entity 'metadata' named entity 'doi' named entity 'MAY BE' named entity 'FORMATTING' named entity 'COVER' named entity 'CHOM' named entity 'JOURNAL '

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