About: A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

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About: A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition
Creator	Pirofski, Liise-Anne Chandran, Kartik Dye, John Daily, Johanna Herbert, Andrew Jangra, Rohit Lai, Jonathan Wirchnianski, Ariel Abbasi, O Abbasi, Shawn Barnhill, Jason Bortz, Robert Bortz Iii, Robert Chandran, A Dieterle, M Fels, J Florez, Catalina Florez, E Georgiev, George Georgiev, R Haslwanter, Denise Jangra, K Kimmel, A Kimmel, Duncan Lasso, A Lasso, Gorka Laudermilch, Ethan Laudermilch, J Malonis, Ryan Mengotto, Amanda Mengotto, C Quiroz, Jose Vergnolle, Olivia Wirchnianski, R
source	Elsevier; Medline; PMC
abstract	Summary There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the availability of robust, scalable, and readily deployable surrogate viral assays to screen antiviral humoral responses, define correlates of immune protection, and down-select candidate antivirals. Here, we generate a highly infectious recombinant vesicular stomatitis virus (VSV) bearing the SARS-CoV-2 spike glycoprotein S as its sole entry glycoprotein and show that this recombinant virus, rVSV-SARS-CoV-2 S, closely resembles SARS-CoV-2 in its entry-related properties. The neutralizing activities of a large panel of COVID-19 convalescent sera can be assessed in a high-throughput fluorescent reporter assay with rVSV-SARS-CoV-2 S, and neutralization of rVSV-SARS-CoV-2 S and authentic SARS-CoV-2 by spike-specific antibodies in these antisera is highly correlated. Our findings underscore the utility of rVSV-SARS-CoV-2 S for the development of spike-specific therapeutics and for mechanistic studies of viral entry and its inhibition.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1016/j.chom.2020.06.020
bibo:pmid	32738193
has license	els-covid
sha1sum (hex)	b9e8043f5b6c168cd2aea5641b546ea4623b8fd3
schema:url	https://doi.org/10.1016/j.chom.2020.06.020
resource representing a document's title	A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition
has PubMed Central identifier	PMC7332447
has PubMed identifier	32738193
schema:publication	Cell Host Microbe
resource representing a document's body	covid:b9e8043f5b6c168cd2aea5641b546ea4623b8fd3#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'cell' named entity 'IMMUNE PROTECTION' named entity 'ANTIVIRAL' named entity 'SARS-COV-2 SPIKE GLYCOPROTEIN' named entity 'SOLE' named entity 'COVID-19' named entity 'DEVELOPMENT' named entity 'STUDIES' named entity 'HTTPS' named entity 'CONTINGENT' named entity 'vesicular stomatitis virus' named entity 'recombinant' named entity 'highly' named entity 'https' named entity 'cell' named entity 'scalable' named entity 'closely resembles' named entity 'SARS-CoV-2' named entity 'doi' named entity 'SARS-CoV-2' named entity 'cell entry' named entity 'vesicular stomatitis virus' named entity 'angiotensin-converting enzyme 2' named entity 'antiserum' named entity 'RBD' named entity 'deletions' named entity 'glycoprotein' named entity 'infection' named entity 'supernatants' named entity 'COVID' named entity 'nuclei' named entity 'fluorescence microscope' named entity 'BSL-2' named entity 'plasmid' named entity 'mAb' named entity 'transfecting' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'virus' named entity 'SARS-CoV-2' named entity 'nonsense mutations' named entity 'SDS-PAGE' named entity 'cysteine' named entity 'subcellular localization' named entity 'centrifugation' named entity 'evolution' named entity 'gene'

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