About: Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015

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About: Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015
Creator	Alejandre-Garcia, Alejandro Castillejos-Lopez, Manuel Hernandez, Andres Moreno-Valencia, Yazmin Perez-Padilla, Rogelio Barbachano-Guerrero, Arturo Dominguez, Aaron Miliar-Garcia, Angel Coronel-Tellez, Rodrigo Romero-Espinoza, Jose Vazquez-Perez, Joel
Source	Medline; PMC
abstract	BACKGROUND: Acute asthma exacerbations and pneumonia are important causes of morbidity and mortality in children and may coexist in the same children, although symptom overlap may lead to difficulties in diagnosis. Microbial and viral diversity and differential abundance of either may play an important role in infection susceptibility and the development of acute and chronic respiratory diseases. OBJECTIVES: To describe the virome and bacteriome present in the upper respiratory tract of hospitalized children with a clinical diagnosis of asthma and pneumonia during an acute exacerbation and an acute respiratory illness ARI episode respectively. METHODS: During the winter seasons of 2013–2014 and 2014–2015, 134 nasopharyngeal swabs samples of children <15 years of age with ARI hospitalized at a referral hospital for respiratory diseases were selected based on clinical diagnosis of asthma or pneumonia. The virome and bacteriome were characterized using Whole Genome Sequencing (WGS) and in-house bioinformatics analysis pipeline. RESULTS: The Asthma group was represented mainly by RV-C, BoV-1 and RSV-B and the pneumonia group by Bacteriophage EJ-1 and TTMV. TTV was found in both groups with a similar amount of reads. About bacterial composition Moraxella catarrhalis, Propionibacterium acnes and Acinetobacter were present in asthma and Veillonella parvula and Mycoplasma pneumoniae in pneumonia. Streptococcus pneumoniae and Haemophilus influenzae were mostly found with both asthma and pneumonia. CONCLUSIONS: Our results show a complex viral and bacterial composition in asthma and pneumonia groups with a strong association of RV-C presence in asthmatic children. We observed Streptococcus pneumoniae and Haemophilus influenzae concurrently in both groups.
has issue date	2018-02-15(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0192878
bibo:pmid	29447223
has license	cc-by
sha1sum (hex)	ba3179ae7ea6877b7b76e048959e97cc0012f5fc
schema:url	https://doi.org/10.1371/journal.pone.0192878
resource representing a document's title	Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015
has PubMed Central identifier	PMC5813968
has PubMed identifier	29447223
schema:publication	PLoS One
resource representing a document's body	covid:ba3179ae7ea6877b7b76e048959e97cc0012f5fc#body_text
is schema:about of	named entity 'differential' named entity 'chronic' named entity 'PNEUMONIA' named entity 'MORBIDITY AND MORTALITY' named entity 'DEVELOPMENT' named entity 'DIFFICULTIES' named entity 'ROLE' named entity 'CHRONIC' named entity 'IMPORTANT' named entity 'DIAGNOSIS' named entity 'SUSCEPTIBILITY' named entity 'ACUTE ASTHMA' named entity 'PNEUMONIA' named entity 'LEAD' named entity '2015' named entity 'VIRAL' named entity 'INFECTION' named entity 'ABUNDANCE' named entity 'EITHER' named entity 'MICROBIAL' named entity 'RESPIRATORY DISEASES' named entity 'CHARACTERIZATION' named entity 'CHILDREN' named entity 'WINTER' named entity 'SEASONS' named entity 'DIVERSITY' named entity 'CHILDREN' named entity 'CAUSES' named entity 'DIFFERENTIAL' named entity 'OVERLAP' named entity 'PLAY' named entity 'MEXICO CITY' named entity 'ASTHMA' named entity 'ASTHMA EXACERBATIONS' named entity 'ACUTE' named entity 'SYMPTOM' named entity 'pneumonia' named entity 'mortality' named entity 'morbidity' named entity 'asthma exacerbations' named entity 'pneumonia' named entity 'symptom' named entity 'infection' named entity 'asthma' named entity 'Virome' named entity 'pneumonia' named entity 'TTV' named entity 'Acinetobacter' named entity 'Streptococcus' named entity 'pneumonia' named entity 'Herpesviridae' named entity 'viral infections' named entity 'viruses' named entity 'qPCR' named entity 'asthma' named entity 'RV-C' named entity 'pediatric patients' named entity 'Thermo Scientific' named entity 'pneumonia' named entity 'Anellovirus' named entity 'random hexamer' named entity 'Moraxella' named entity 'Thermo Scientific' named entity 'asthma' named entity 'pneumonia' named entity 'SARI' named entity 'genome' named entity 'viruses' named entity 'clinical signs' named entity 'influenza virus' named entity 'RT-qPCR'

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