About: Early risk factors of the exacerbation of Coronavirus disease 2019 pneumonia

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early risk factors of the exacerbation of Coronavirus disease 2019 pneumonia
Creator	Li, Min Wang, Lin Hu, Shun-Lin Li, Huan-Tian Li, Huantian Wang, Chang-Zheng
Source	Medline; PMC
abstract	The purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with SARS‐CoV‐2, including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest CT. All laboratory examination were measured within first 24 hours after admission, and chest CT were performed before admission. 56 (65.9%) patients had a history of exposure to Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (p=0.003) and coronary heart disease (p=0.017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (p<0.001). Severe and critical patients showed higher WBC count (p=0.006), NEU count (p=0.001), NEU% (p=0.002), PCT (p=0.011), CRP (p=0.003), PT (p=0.035), D‐dimer (p=0.025), AST (p=0.006), and lower LYM count (p=0.019), LYM% (p=0.001), ALB (p<0.001). Logistic regression analysis showed NEU count is a independent risk factor for deterioration, with the threshold of 6.5×10(9)·L(‐1). We concluded that the laboratory independent risk factor for the progression of COVID‐19 pneumonia is NEU count. In addition, COVID‐19 patients with bilateral lung involvement or multiple lobes involvement should be taken seriously and actively treated to prevent deterioration of the disease. This article is protected by copyright. All rights reserved.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1002/jmv.26071
bibo:pmid	32470167
has license	no-cc
sha1sum (hex)	ba9fbe2ffbb41fa0eb08649517f4ef1412feaf07
schema:url	https://doi.org/10.1002/jmv.26071
resource representing a document's title	Early risk factors of the exacerbation of Coronavirus disease 2019 pneumonia
has PubMed Central identifier	PMC7283729
has PubMed identifier	32470167
schema:publication	J Med Virol
resource representing a document's body	covid:ba9fbe2ffbb41fa0eb08649517f4ef1412feaf07#body_text
is schema:about of	named entity 'risk factor' named entity 'symptoms' named entity 'profile' named entity 'infected' named entity 'severe' named entity 'independent' named entity 'gender' named entity 'ROUTINE' named entity 'SEVERE' named entity 'PERCENTAGE' named entity 'LOBES' named entity 'MEASURED' named entity 'ADMISSION' named entity 'LUNG' named entity 'PROFILE' named entity 'INFECTED' named entity 'HYPERTENSION' named entity 'BILATERAL' named entity 'INDEPENDENT RISK FACTOR' named entity 'CONDITIONS' named entity 'CLINICAL DATA' named entity 'LOWER' named entity 'COVID' named entity 'count' named entity 'CRP' named entity 'count' named entity 'patients' named entity 'pneumonia' named entity 'higher' named entity 'threshold' named entity 'comorbidities' named entity 'lung' named entity 'history' named entity 'regression analysis' named entity 'enzyme' named entity 'WBC' named entity 'dry cough' named entity 'CRP' named entity 'hypertension' named entity 'COVID' named entity 'PCT' named entity 'D-dimer' named entity 'COVID' named entity 'Fisher's exact test' named entity 'FiO2' named entity 'infectious diseases' named entity 'pneumonia' named entity 'Iran' named entity 'virus transmission' named entity 'normal distribution' named entity 'myalgia' named entity 'lesion' named entity 'lung' named entity 'secondary infection' named entity 'covid-19' named entity 'albumin' named entity 'organ' named entity 'National Health Commission' named entity 'adenovirus' named entity 'coagulation' named entity 'cellular immunity' named entity 'risk factor' named entity 'qPCR' named entity 'chloroquine phosphate' named entity 'organ failure' named entity 'fatigue' named entity 'dizziness' named entity 'Chest CT' named entity 'mycoplasma pneumoniae' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'expectorant' named entity 'statistically significant' named entity 'significant difference' named entity 'comorbidities' named entity 'hypertension'

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