About: Ancient recombination events and the origins of hepatitis E virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Ancient recombination events and the origins of hepatitis E virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ancient recombination events and the origins of hepatitis E virus
Creator	White, Peter Kelly, Andrew Netzler, Natalie
Source	Medline; PMC
abstract	BACKGROUND: Hepatitis E virus (HEV) is an enteric, single-stranded, positive sense RNA virus and a significant etiological agent of hepatitis, causing sporadic infections and outbreaks globally. Tracing the evolutionary ancestry of HEV has proved difficult since its identification in 1992, it has been reclassified several times, and confusion remains surrounding its origins and ancestry. RESULTS: To reveal close protein relatives of the Hepeviridae family, similarity searching of the GenBank database was carried out using a complete Orthohepevirus A, HEV genotype I (GI) ORF1 protein sequence and individual proteins. The closest non-Hepeviridae homologues to the HEV ORF1 encoded polyprotein were found to be those from the lepidopteran-infecting Alphatetraviridae family members. A consistent relationship to this was found using a phylogenetic approach; the Hepeviridae RdRp clustered with those of the Alphatetraviridae and Benyviridae families. This puts the Hepeviridae ORF1 region within the “Alpha-like” super-group of viruses. In marked contrast, the HEV GI capsid was found to be most closely related to the chicken astrovirus capsid, with phylogenetic trees clustering the Hepeviridae capsid together with those from the Astroviridae family, and surprisingly within the “Picorna-like” supergroup. These results indicate an ancient recombination event has occurred at the junction of the non-structural and structure encoding regions, which led to the emergence of the entire Hepeviridae family. The Astroviridae capsid is also closely related to the Tymoviridae family of monopartite, T = 3 icosahedral plant viruses, whilst its non-structural region is related to viruses of the Potyviridae; a large family of plant-infecting viruses with a flexible filamentous rod-shaped virion. Thus, we identified a separate inter-viral family recombination event, again at the non-structural/structural junction, which likely led to the creation of the Astroviridae. CONCLUSIONS: In summary, we have shown that new viral families have been created though recombination at the junction of the genome that encodes non-structural and structural proteins, and such recombination events are implicated in the genesis of important human pathogens; HEV, astrovirus and rubella virus. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12862-016-0785-y) contains supplementary material, which is available to authorized users.
has issue date	2016-10-12(xsd:dateTime)
bibo:doi	10.1186/s12862-016-0785-y
bibo:pmid	27733122
has license	cc-by
sha1sum (hex)	bad5ef8da723dbf5a4f3c780260f61c106ca3859
schema:url	https://doi.org/10.1186/s12862-016-0785-y
resource representing a document's title	Ancient recombination events and the origins of hepatitis E virus
has PubMed Central identifier	PMC5062859
has PubMed identifier	27733122
schema:publication	BMC Evol Biol
resource representing a document's body	covid:bad5ef8da723dbf5a4f3c780260f61c106ca3859#body_text
is schema:about of	named entity 'genome' named entity 'recombination' named entity 'Background' named entity 'identified' named entity 'remains' named entity 'recombination' named entity 'virus' named entity 'HUMAN' named entity 'AGENT' named entity 'INDIVIDUAL' named entity 'NON-' named entity 'CREATION' named entity 'PROTEIN ' named entity 'RNA VIRUS' named entity 'SINGLE' named entity 'GENOTYPE' named entity 'BACKGROUND' named entity 'RDRP' named entity 'ENCODED' named entity 'REVEAL' named entity 'RELATED' named entity 'STRUCTURAL PROTEINS' named entity 'PROTEIN SEQUENCE' named entity 'CONFUSION' named entity 'THESE' named entity 'FILAMENTOUS' named entity 'ASTROVIRIDAE' named entity 'POSITIVE' named entity 'TREES' named entity 'RUBELLA VIRUS' named entity 'BENYVIRIDAE' named entity 'PLANT VIRUSES' named entity 'RESULTS' named entity '1992' named entity 'event' named entity 'Hepatitis E virus' named entity 'emergence' named entity 'structural' named entity 'regions' named entity 'ORF1' named entity 'family' named entity 'families' named entity 'viruses' named entity 'times' named entity 'positive sense' named entity 'Results' named entity 'genotype' named entity 'genesis' named entity 'proteins' named entity 'trees' named entity 'recombination' named entity 'HEV' named entity 'Hepeviridae' named entity 'recombination' named entity 'rod-shaped' named entity 'recombination' named entity 'viruses' named entity 'Hepeviridae' named entity 'Hepeviridae' named entity 'virus' named entity 'Benyviridae' named entity 'single-stranded' named entity 'GenBank' named entity 'polyprotein' named entity 'icosahedral' named entity 'Astroviridae' named entity 'Hepeviridae' named entity 'HEV' named entity 'hepatitis E virus' named entity 'polyprotein' named entity 'Benyviridae' named entity 'Hepeviridae' named entity 'IRF3' named entity 'Capsid' named entity 'homology' named entity 'viral infection' named entity 'capsids' named entity 'vertebrate' named entity 'Betaflexiviridae'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software