About: Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Creator	Zhao, Hongyu Asgharian, Hosseinali Farahvashi, Sina Fattahi, Faranak Ghazizadeh, Zaniar Goodarzi, Hani Kalantari, Ali Majd, Homa Natarajan, Pradeep Ramirez, Jonathan Richter, Mikayla Samuel, Ryan Zekavat, Maryam
topic	covid:bb33bde802382ba37ed9f048c90b96f1e99948fd#this
Source	BioRxiv; Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to a global health crisis, and yet our understanding of the disease pathophysiology and potential treatment options remains limited. SARS-CoV-2 infection occurs through binding and internalization of the viral spike protein to angiotensin converting enzyme 2 (ACE2) on the host cell membrane. Lethal complications are caused by damage and failure of vital organs that express high levels of ACE2, including the lungs, the heart and the kidneys. Here, we established a high-throughput drug screening strategy to identify therapeutic candidates that reduce ACE2 levels in human embryonic stem cell (hESC) derived cardiac cells. Drug target analysis of validated hit compounds, including 5 alpha reductase inhibitors, revealed androgen signaling as a key modulator of ACE2 levels. Treatment with the 5 alpha reductase inhibitor dutasteride reduced ACE2 levels and internalization of recombinant spike receptor binding domain (Spike-RBD) in hESC-derived cardiac cells and human alveolar epithelial cells. Finally, clinical data on coronavirus disease 2019 (COVID-19) patients demonstrated that abnormal androgen states are significantly associated with severe disease complications and cardiac injury as measured by blood troponin T levels. These findings provide important insights on the mechanism of increased disease susceptibility in male COVID-19 patients and identify androgen receptor inhibition as a potential therapeutic strategy.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1101/2020.05.12.091082
bibo:pmid	32511360
has license	cc-by-nc-nd
sha1sum (hex)	bb33bde802382ba37ed9f048c90b96f1e99948fd
schema:url	https://doi.org/10.1101/2020.05.12.091082
resource representing a document's title	Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
has PubMed Central identifier	PMC7263488
has PubMed identifier	32511360
schema:publication	bioRxiv
resource representing a document's body	covid:bb33bde802382ba37ed9f048c90b96f1e99948fd#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/bb33bde802382ba37ed9f048c90b96f1e99948fd
is schema:about of	named entity 'troponin T' named entity 'levels' named entity 'reductase' named entity 'identify' named entity 'recombinant' named entity 'modulator' named entity 'Lethal' named entity 'inhibitor' named entity 'human' named entity 'male' named entity 'levels' named entity 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'caused' named entity 'These' named entity 'cardiac cells' named entity 'Treatment' named entity 'serum' named entity 'down-regulation' named entity 'degree centrality' named entity 'molecular level' named entity 'viral entry' named entity 'TMPRSS2' named entity 'UK Biobank' named entity 'cardiomyocytes' named entity 'COVID' named entity 'Protein-protein interaction network' named entity 'serine' named entity 'COVID-19 testing' named entity 'drug target' named entity 'hypertensive disorder' named entity 'High-throughput screening' named entity 'Seurat' named entity 'preprint' named entity 'gene ontology' named entity 'fastq' named entity 'cellular membrane' named entity 'chemical library' named entity 'protein' named entity 'fibroblasts' named entity 'staining' named entity 'cardiomyocytes' named entity 'regulatory mechanisms' named entity 'z-score' named entity 'primary antibody' named entity 'gene' named entity 'z-scores' named entity 'BMI' named entity 'androgen' named entity 'protein' named entity 'receptor' named entity 'type 2 Diabetes Mellitus' named entity 'white British' named entity 'immunofluorescent' named entity 'p-values' named entity 'cell types' named entity 'ChIP-seq' named entity 'scikit-learn' named entity 'peer review' named entity 'CC-BY-NC-ND 4.0' named entity 'FDA' named entity 'sensitivity analysis' named entity 'hypertension' named entity 'immunofluorescence' named entity 'gene' named entity 'validation set' named entity 'esophagus' named entity 'RBD'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software