About: Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis

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About: Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis
Creator	Bagshaw, Sean Andersen, Sarah Deschamps, Jean Featherstone, Robin Sebastianski, Meghan Senaratne, Janek Vandermeer, Ben Webber, Jordan
Source	PMC
abstract	BACKGROUND: Predicting successful liberation from mechanical ventilation (MV) in critically ill patients is challenging. Brain natriuretic peptide (BNP) has been proposed to help guide decision-making for readiness to liberate from MV following a spontaneous breathing trial (SBT). METHODS: We performed a systematic review and meta-analysis of randomized and prospective observational studies that measured BNP levels at the time of SBT in patients receiving MV. The primary endpoint was successful liberation from MV (absence of reintubation or non-invasive ventilation at 48 h). Statistical analyses included bi-variate and Moses-Littenberg models and DerSimonian-Laird pooling of areas under ROC curve (AUROC). RESULTS: A total of 731 articles were screened. Eighteen adult and 2 pediatric studies were fulfilled pre-specified eligibility. The measure of the relative variation of BNP during SBT (ΔBNP%) after exclusion of SBT failure by clinical criteria in adults yielded a sensitivity and specificity of 0.889 [0.831–0.929] and 0.828 [0.730–0.896] for successful liberation from MV, respectively, with a pooled AUROC of 0.92 [0.88–0.97]. The pooled AUROC for any method of analysis for absolute variation of BNP (ΔBNP), pre-SBT BNP, and post-SBT BNP were 0.89 [0.83–0.95], 0.77 [0.63–0.91], and 0.85 [0.80–0.90], respectively. CONCLUSION: The relative change in BNP during a SBT has potential value as an incremental tool after successful SBT to predict successful liberation from MV in adults. There is insufficient data to support the use of BNP in children or as an alternate test to clinical indices of SBT, or the use of ΔBNP, BNP-pre, and BNP-post as an alternate or incremental test. TRIAL REGISTRATION: PROSPERO CRD42018087474 (6 February 2018)
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1186/s13054-020-2823-9
bibo:pmid	32393393
has license	cc-by
sha1sum (hex)	bb42e73e147be621fba5ba1299ddd52117b38e0c
schema:url	https://doi.org/10.1186/s13054-020-2823-9
resource representing a document's title	Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis
has PubMed Central identifier	PMC7216735
has PubMed identifier	32393393
schema:publication	Crit Care
resource representing a document's body	covid:bb42e73e147be621fba5ba1299ddd52117b38e0c#body_text
is schema:about of	named entity 'TRIAL' named entity 'LIBERATION' named entity 'readiness' named entity 'mechanical ventilation' named entity 'successful' named entity 'patients' named entity 'natriuretic peptide' named entity 'mechanical ventilation' named entity 'Brain natriuretic peptide' named entity 'decision-making' named entity 'mechanical ventilation' named entity 'non-invasive ventilation' named entity 'confidence regions' named entity 'BNP' named entity 'BNP' named entity 'Thomson Reuters' named entity 'PROSPERO' named entity 'ROC curve' named entity 'BNP' named entity 'SBT' named entity 'meta-analysis' named entity 'true positive' named entity 'ROC analysis' named entity 'NT-proBNP' named entity 'half-life' named entity 'SBT' named entity 'National Guidelines' named entity 'BNP' named entity 'SBT' named entity 'BNP' named entity 'SBT' named entity 'odds ratio' named entity 'SBT' named entity 'BNP' named entity 'extubation' named entity 'Moses' named entity 'BNP' named entity 'BNP' named entity 'BNP' named entity 'BNP' named entity 'BNP' named entity 'BNP' named entity 'SBT' named entity 'failure analysis' named entity 'sensitivity and specificity' named entity 'SBT' named entity 'stridor' named entity 'critically ill patients' named entity 'failure analysis' named entity 'BNP' named entity 'cardiomyocytes' named entity 'BNP' named entity 'mechanical ventilation' named entity 'meta-analysis' named entity 'American Thoracic Society' named entity 'BNP' named entity '1, 2' named entity 'SBT' named entity 'reintubation' named entity 'AUROC' named entity 'extubation' named entity 'NT-ProBNP' named entity 'SBT' named entity 'intensive care unit' named entity 'NRI' named entity 'sensitivity and specificity' named entity 'heart surgery' named entity 'CPG' named entity 'stratified analysis' named entity 'odds ratio' named entity 'ROC curve' named entity 'SBT' named entity 'SBT' named entity 'SBT'

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